COVID-19 Incidence and Mortality in Patients Recovered from Tuberculosis: A Retrospective Cohort Analysis of the National Health Insurance in Republic of Korea.

IF 1.1 4区 医学 Q4 INFECTIOUS DISEASES
Junghee Hong, Chulyong Park, Kiook Baek
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引用次数: 0

Abstract

Tuberculosis (TB) is an endemic respiratory disease in several countries, including South Korea. The coronavirus disease 2019 (COVID-19) may pose greater risks to individuals with pre-existing respiratory diseases, but there are few reports on how the post-recovery state from TB affects COVID-19 infection and mortality. This study aimed to investigate the susceptibility and mortality of COVID-19 in patients with a history of TB. We retrospectively analyzed data from the National Health Insurance Service of Korea. We extracted individuals with TB from 2011 to 2019 and matched them with a population-based control group. The main outcomes were COVID-19 incidence and death within 30 days of infection. The study included 138,278 matched pairs of individuals with and without a history of TB. COVID-19 incidence was slightly lower in the TB group (38.0% vs. 38.4%, P-value = 0.023). Subgroup analysis showed significantly lower COVID-19 incidence in the pulmonary TB group compared to controls (P-value = 0.001). However, the mortality rate was higher in the TB group (0.9% vs. 0.7%, P-value < 0.001). This study showed that TB has a slightly protective effect against COVID-19 infection but increases the mortality rate. These findings will guide future research on the interaction between TB and COVID-19.

COVID-19在结核病康复患者中的发病率和死亡率:韩国国民健康保险的回顾性队列分析。
结核病(TB)是包括韩国在内的几个国家的一种地方性呼吸道疾病。2019冠状病毒病(COVID-19)可能对已有呼吸道疾病的个体构成更大的风险,但关于结核病康复后状态如何影响COVID-19感染和死亡率的报道很少。本研究旨在调查有结核病史的患者中COVID-19的易感性和死亡率。我们回顾性分析了韩国国民健康保险服务的数据。我们提取了2011年至2019年的结核病患者,并将其与以人群为基础的对照组进行匹配。主要结局为感染后30天内的COVID-19发病率和死亡。该研究包括138278对有或没有结核病史的配对个体。TB组的COVID-19发病率略低(38.0%比38.4%,p值= 0.023)。亚组分析显示,与对照组相比,肺结核组的COVID-19发病率显著降低(p值= 0.001)。然而,结核病组的死亡率更高(0.9% vs. 0.7%, p值< 0.001)。这项研究表明,结核病对COVID-19感染有轻微的保护作用,但会增加死亡率。这些发现将指导未来对结核病与COVID-19相互作用的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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