The Vital Role of Long Non-Coding RNA SUMO1P3 in the Regulation of Human Cancer: Current Perspectives and Future Challenges.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-07-29 DOI:10.2174/0115680266383856250715062654

Jingjie Yang, Yuzhang Wei, Chengran Gao, Zihang Wang, Yulong Liu, Haodong He, Hao Zhou, Guihua Liao, Gang Zhou, Chengfu Yuan

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Abstract

Small Ubiquitin-like Modifier 1 Pseudogene 3 (SUMO1P3) is a novel long non-coding RNA (lncRNA) located at the 1q23.2 locus of the human chromosome. Recent evidence indicates that SUMO1P3 is aberrantly upregulated in nine types of human cancer and functions as an oncogene. Elevated SUMO1P3 expression is strongly associated with unfavorable clinicopathological features and poor prognosis in eight cancer types. Mechanistically, SUMO1P3 functions as a miRNA sponge, an epigenetic regulator, and directly interacting with proteins. It activates key signaling pathways, such as the Wnt/β-catenin and AKT pathways, and regulates Epithelial- Mesenchymal Transition (EMT), which facilitates cancer progression and therapy resistance. Due to its diverse functional roles, SUMO1P3 emerges as a promising diagnostic and prognostic biomarker, as well as a potential therapeutic target in precision oncology. This review provides a comprehensive summary of current research on SUMO1P3, highlighting its regulatory mechanisms, biological functions, and clinical significance in cancer biology.

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长链非编码RNA SUMO1P3在人类癌症调控中的重要作用：目前的观点和未来的挑战

小泛素样修饰物1伪基因3 （SUMO1P3）是一种位于人类染色体1q23.2位点的新型长链非编码RNA （lncRNA）。最近的证据表明，SUMO1P3在九种人类癌症中异常上调，并作为致癌基因发挥作用。在8种癌症类型中，SUMO1P3表达升高与不良的临床病理特征和不良预后密切相关。从机制上讲，SUMO1P3作为miRNA海绵，一种表观遗传调节剂，直接与蛋白质相互作用。它激活关键信号通路，如Wnt/β-catenin和AKT通路，并调节上皮-间充质转化（Epithelial- Mesenchymal Transition， EMT），促进癌症进展和治疗耐药。由于其多种功能作用，SUMO1P3成为一种有前景的诊断和预后生物标志物，以及精准肿瘤学的潜在治疗靶点。本文就SUMO1P3的研究现状进行综述，重点介绍其调控机制、生物学功能及其在肿瘤生物学中的临床意义。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.