Cannabinoids drive feeding through AgRP neurons

IF 2.6 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-07-28 DOI:10.1016/j.brainres.2025.149857

Yavuz Yavuz , Habibe Goren , Bayram Yilmaz

引用次数: 0

Abstract

The endocannabinoid system regulates energy balance and feeding behavior, primarily through cannabinoid type-1 receptors (CB1Rs). While CB1R activation is known to increase food intake, the role of agouti-related peptide (AgRP) neurons of the arcuate nucleus (ARC) in this process remains unclear. Using slice electrophysilogy we found that the CB1R agonist ACEA reduced inhibitory postsynaptic currents (sIPSCs) in AgRP neurons. Ablating AgRP neurons diminished the hyperphagic and anxiolytic effects of CB1R agonist ACEA, suggesting that intact AgRP neuron circuits are necessary. Conversely, CB1R antagonism in AgRP-ablated mice increased food intake, suggesting compensatory mechanisms. These results suggest that cannabinoid action on the synapses on AgRP neurons may contribute its feeding regulatory actions.

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大麻素通过AgRP神经元驱动进食。

内源性大麻素系统主要通过大麻素1型受体（CB1Rs）调节能量平衡和摄食行为。虽然已知CB1R激活会增加食物摄入量，但弓形核（ARC）的针刺相关肽（AgRP）神经元在这一过程中的作用尚不清楚。通过切片电生理学，我们发现CB1R激动剂ACEA降低了AgRP神经元的抑制性突触后电流（sIPSCs）。消融AgRP神经元可减少CB1R激动剂ACEA的贪食和抗焦虑作用，表明完整的AgRP神经元回路是必要的。相反，在agrp消融的小鼠中，CB1R拮抗剂增加了食物摄入量，提示代偿机制。这些结果表明大麻素对AgRP神经元突触的作用可能参与了其摄食调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.