Fast-Scan Anodic Stripping Voltammetry for the Ecofriendly Detection of Anticancer Perillyl Alcohol Using Activated Graphite Sensor

IF 2.3 3区化学 Q2 CHEMISTRY, ANALYTICAL

Electroanalysis Pub Date : 2025-08-01 DOI:10.1002/elan.70018

Mona Elfiky, Maie Mousa, Nehal Salahuddin

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Abstract

Perillyl alcohol (POH) is a natural compound presented in essential oils extracted from plants, recognized for its capacity to stimulate apoptosis in tumor cells while leaving normal cells unharmed. The present study has established a square-wave adsorptive anodic stripping voltammetric (SW-AdASV) technique for the detection of POH in both bulk, and biological fluids, utilizing an activated graphite sensor (AGPS). The electrochemical oxidation performance of POH was studied via cyclic voltammetry and subsequently optimized with SW-AdASV technique. Under the standard operational conditions, linear calibration curves for POH were obtained within concentration ranges of 0.001–0.013 nM and 0.003–0.018 nM. The detection limits (LODs) for bulk and human serum were evaluated to be 0.3 pM and 0.9 pM, respectively. Moreover, The AGPS effectively detected POH concentrations in human serum during routine analyses, with no interference from other serum components. Additionally, it demonstrated satisfactory repeatability, reproducibility, and a storage stability of 94.54%.

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活性石墨传感器快速扫描阳极溶出伏安法环保检测抗癌紫苏醇

紫苏醇（Perillyl alcohol， POH）是一种天然化合物，存在于从植物中提取的精油中，因其刺激肿瘤细胞凋亡而不伤害正常细胞的能力而受到认可。本研究建立了一种方波吸附阳极溶出伏安法（SW-AdASV）技术，利用活性石墨传感器（AGPS）检测散装流体和生物流体中的POH。通过循环伏安法研究了POH的电化学氧化性能，并利用SW-AdASV技术对其进行了优化。在标准操作条件下，在0.001 ~ 0.013 nM和0.003 ~ 0.018 nM的浓度范围内获得了POH的线性校准曲线。测定了大血清和人血清的检出限分别为0.3 pM和0.9 pM。此外，在常规分析中，AGPS可以有效地检测人血清中的POH浓度，而不受其他血清成分的干扰。结果表明，该方法重复性好，重现性好，贮存稳定性为94.54%。

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来源期刊

Electroanalysis 化学-电化学

CiteScore

6.00

自引率

3.30%

发文量

222

审稿时长

2.4 months

期刊介绍： Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications. Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.