Advanced solid materials for the extraction of drugs from biological fluids

IF 6.5 Q1 CHEMISTRY, ANALYTICAL

Advances in Sample Preparation Pub Date : 2025-08-01 DOI:10.1016/j.sampre.2025.100202

P. García-Atienza, A. García-Juan, S. Armenta, J.M. Herrero-Martínez, H. Martínez-Pérez-Cejuela

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Abstract

The determination of drugs in biological fluids is essential across various fields, including toxicological analysis, pharmacokinetic studies, and the development of new pharmaceutical products, among others. However, the complexity of biological matrices—due to the presence of endogenous compounds and the typically low concentrations of target analytes—needs efficient sample preparation strategies alongside high-performance instrumentation to achieve the sensitivity and selectivity required in modern analytical chemistry. In response to these challenges, recent advancements have focused on the development of advanced solid materials and their integration with sample preparation techniques. This review highlights recent progress in sorbents with enhanced selectivity, engineered materials such as crystalline frameworks, and the use of biopolymers as natural sorbents for drug analysis in biofluids. Additionally, the application of 3D-printed materials for the fabrication of extraction devices is presented. The article also provides insights into emerging trends and future directions in this evolving field.

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用于从生物液体中提取药物的先进固体材料

生物液体中药物的测定在各个领域都是必不可少的，包括毒理学分析、药代动力学研究和新药品的开发等。然而，生物基质的复杂性——由于内源性化合物的存在和目标分析物的典型低浓度——需要高效的样品制备策略和高性能仪器来实现现代分析化学所需的灵敏度和选择性。为了应对这些挑战，最近的进展集中在先进固体材料的开发及其与样品制备技术的集成上。本文综述了近年来在选择性吸附剂、工程材料（如晶体框架）以及生物聚合物作为天然吸附剂用于生物流体中药物分析方面的进展。此外，还介绍了3d打印材料在提取装置制造中的应用。本文还提供了对这个不断发展的领域的新兴趋势和未来方向的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Sample Preparation

CiteScore

3.50

自引率

0.00%

发文量