Evaluating the sustainability and commercial viability of conventional and traditional bone tissue scaffold fabrication methods

IF 9.6 1区 环境科学与生态学 Q1 ENVIRONMENTAL STUDIES
Lillian Tsitsi Mambiri , Riley Guillory , Dilip Depan
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Abstract

Bone tissue engineering (BTE) is critical for addressing bone defects caused by aging populations, chronic diseases, and millions of annual road injuries, yet its potential is hampered by high costs, regulatory delays that deter investment, and healthcare's environmental footprint, which accounts for 8.5 % of the United States' emissions and continues to rise. BTE advancement must prioritize affordability, regulatory efficiency, and climate-conscious innovation to ensure equitable access and sustainability. This work conducts a comparative life cycle assessment (LCA), techno-economic analysis (TEA), and entropy-weighted sustainability indices (SI), a data-driven overall score that weighs economic and environmental metrics by their variability, of stereolithography (SLA) three-dimensional (3D) printing and electrospinning (ES) for polycaprolactone-based scaffold preparation. Results show SLA reduces energy demand per kilogram of scaffold compared to ES, attributed to ES's energy-intensive solvent evaporation and high-voltage fiber formation. When bioactive nanofillers were incorporated, SLA remained cost-competitive and environmentally favorable, whereas ES showed steep increases in energy use, solvent consumption, and ecotoxicity, largely attributed to chloroform. Entropy-weighted SI values reflected these trends: SLA led the ranking, its nanofiller variant remained viable, while ES (with and without nanofillers) performed poorest due to compounded environmental and economic burdens. Adopting solvent recovery systems, such as condensation and closed-loop recycling as well as green solvents and renewable energy, could trim the high energy demand and solvent-intensive processes.

Abstract Image

评估传统和传统骨组织支架制造方法的可持续性和商业可行性
骨组织工程(BTE)对于解决由人口老龄化、慢性病和每年数百万的道路伤害引起的骨缺损至关重要,但其潜力受到高成本、阻碍投资的监管延误以及医疗保健的环境足迹的阻碍,后者占美国排放量的8.5%,并且还在继续上升。BTE的发展必须优先考虑可负担性、监管效率和气候意识创新,以确保公平获取和可持续性。这项工作进行了生命周期评估(LCA)、技术经济分析(TEA)和熵加权可持续性指数(SI)的比较,这是一种数据驱动的总分,通过其可变性来衡量经济和环境指标,用于聚己内酯基支架制备的立体光刻(SLA)、三维(3D)打印和静电纺丝(ES)。结果表明,与ES相比,SLA降低了每千克支架的能量需求,这归功于ES的高能耗溶剂蒸发和高压纤维形成。当加入生物活性纳米填料时,SLA仍然具有成本竞争力和环境优势,而ES则显示出能源使用、溶剂消耗和生态毒性的急剧增加,主要归因于氯仿。熵加权SI值反映了这些趋势:SLA排名第一,其纳米填料变体仍然可行,而ES(有或没有纳米填料)由于复杂的环境和经济负担而表现最差。采用溶剂回收系统,如冷凝和闭环回收,以及绿色溶剂和可再生能源,可以减少高能耗和溶剂密集型工艺。
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来源期刊
Sustainable Production and Consumption
Sustainable Production and Consumption Environmental Science-Environmental Engineering
CiteScore
17.40
自引率
7.40%
发文量
389
审稿时长
13 days
期刊介绍: Sustainable production and consumption refers to the production and utilization of goods and services in a way that benefits society, is economically viable, and has minimal environmental impact throughout its entire lifespan. Our journal is dedicated to publishing top-notch interdisciplinary research and practical studies in this emerging field. We take a distinctive approach by examining the interplay between technology, consumption patterns, and policy to identify sustainable solutions for both production and consumption systems.
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