Organophotoredox‐Catalyzed Functionalization of Spiro‐Dihydroquinazolinones with Morita–Baylis–Hilman Adducts

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-07-30 DOI:10.1002/adsc.70043

Saikat Mondal, Bathula Maheswari, Abuthayir Mohamathu Ghouse, Srirama Murthy Akondi

引用次数: 0

Abstract

An organophotoredox‐catalyzed, chemo‐ and regio‐selective C–C bond formation between spiro‐dihydroquinazolinones and Morita–Baylis–Hilman adducts has been reported. This transformation proceeds via an aromatization driven deconstructive formation of an alkyl radical and its subsequent selective addition at SN2′ position of MBH acetates, resulting in alkene‐ containing quinazolinones. Mild reaction conditions, good substrate‐scope and further modification of resultant products are the noteworthy accomplishments of this methodology.

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Morita-Baylis-Hilman加合物催化的螺-二氢喹唑啉酮有机光氧化还原功能化

一种有机光氧化还原催化，化学和区域选择性的C-C键在螺-二氢喹唑啉酮和森塔-贝利斯-希尔曼加合物之间形成。这种转化是通过芳构化驱动的烷基自由基的解构形成及其随后在MBH醋酸酯的SN2 '位置的选择性加成进行的，从而产生含烯烃的喹唑啉酮。温和的反应条件，良好的底物范围和产物的进一步改性是该方法值得注意的成就。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.