Analysis of the prospects of new therapeutic agents for the treatment of rheumatoid arthritis.

Alexander V Blagov, Nikolay A Orekhov, Dmitry F Beloyartsev, Alexey V Churov, Tatiana I Kovyanova, Irina A Starodubtseva, Vasily N Sukhorukov, Alexander N Orekhov
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Abstract

Rheumatoid arthritis (RA), a chronic autoimmune disease, is one of the major research themes in medicine. The current therapies have their limitations and cannot completely cure RA, but new therapeutic strategies are being proposed to reduce the shortcomings of approved drugs. This review will consider new potential treatment strategies for RA, including T-cell therapy, genetic editing and epigenetic regulation, what advantages and disadvantages they have and to what pathological target in RA they are directed.

类风湿关节炎治疗新药物的前景分析。
类风湿关节炎(Rheumatoid arthritis, RA)是一种慢性自身免疫性疾病,是目前医学研究的重要课题之一。目前的治疗方法有其局限性,不能完全治愈RA,但新的治疗策略正在提出,以减少已批准药物的缺点。这篇综述将考虑新的潜在治疗RA的策略,包括t细胞治疗、基因编辑和表观遗传调控,它们有什么优点和缺点,以及它们针对RA的病理靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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