[Factors and conditions affecting transcortin production and function in blood plasma].

A Chevais, D G Beltsevich, K Sh Gadzhieva, H V Bagirova, A K Ebzeeva, A N Romanova, M M Gadzhimuradova, G A Melnichenko
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Abstract

It is well-established that the majority of steroid hormones in the bloodstream are in a bound state, complexed with carrier proteins. Transcortin (corticosteroid-binding globulin, SERPINA6) serves as the principal transport protein for steroid hormones and is predominantly synthesized in the liver. Its primary function is to regulate the systemic bioavailability of glucocorticoids and mineralocorticoids. This review article presents an analysis of the existing literature on the impact of various factors and conditions on Transcortin, encompassing its synthesis, secretion, and affinity, as well as its role in physiological and pathophysiological processes within the human body. A reduction in Transcortin levels has been observed in several contexts, including old age, obesity, and metabolic syndrome. Additionally, this decrease is evident in the presence of cirrhosis, sepsis, polytrauma, extensive burns, and during surgical interventions. The concentration of Transcortin in the bloodstream can be influenced by a variety of medications. For instance, estrogen therapy, such as combined oral contraceptives, has been shown to induce a significant increase in Transcortin levels. Conversely, the administration of glucocorticoids has been associated with a decrease in Transcortin levels. Furthermore, this review article includes an analysis of studies that have investigated the influence of Transcortin and alterations in its blood levels in the context of endogenous hypercortisolism. These studies contribute to a deeper understanding of the complex interplay between Transcortin and steroid hormone regulation in various physiological and pathological conditions.

[影响血浆中转化素产生和功能的因素和条件]。
血液中的大多数类固醇激素都处于结合状态,与载体蛋白络合。转肾上腺素(皮质类固醇结合球蛋白,SERPINA6)是类固醇激素的主要转运蛋白,主要在肝脏合成。其主要功能是调节糖皮质激素和矿皮质激素的全身生物利用度。本文综述了各种因素和条件对转肾上腺素的影响,包括其合成、分泌和亲和力,以及其在人体生理和病理生理过程中的作用。在一些情况下,包括老年、肥胖和代谢综合征,可观察到转肾上腺素水平的降低。此外,在肝硬化、败血症、多发创伤、大面积烧伤和手术干预期间,这种下降是明显的。血液中转甲素的浓度可受到多种药物的影响。例如,雌激素治疗,如联合口服避孕药,已被证明可诱导转肾上腺素水平显著增加。相反,糖皮质激素的施用与转肾上腺素水平的降低有关。此外,这篇综述文章还分析了内源性高皮质醇血症背景下Transcortin及其血液水平变化的影响。这些研究有助于更深入地了解在各种生理和病理条件下转肾上腺素和类固醇激素调节之间的复杂相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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