Retrospective Evaluation of Acute Kidney Injury and Its Association With Severity and Outcome in Small Animal Trauma Patients: 387 Cases (2017–2021)

IF 1.2 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2025-07-29 DOI:10.1111/vec.70006

Emily Jane Stacey, Stefano Cortellini, Laura Pearl Cole

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引用次数: 0

Abstract

Objective

To describe the prevalence of acute kidney injury (AKI) in canine and feline trauma and to determine associations between AKI and trauma severity, outcome, species, and other factors.

Design

Analysis of cases submitted by one hospital to the Veterinary Committee on Trauma registry between April 2017 and February 2021 that had blood creatinine concentration measured within 6 h of presentation after trauma.

Setting

University teaching hospital in the United Kingdom.

Animals

A total of 220 canine and 167 feline trauma patients.

Measurements and Main Results

Azotemic AKI was defined as creatinine concentration > 140 µmol/L (1.58 mg/dL) and subgrouped by fluid responsiveness according to the International Renal Interest Society. Hospital-acquired AKI (HAAKI) was defined as a serial increase in creatinine concentration ≥ 26.4 µmol/L (≥ 0.3 mg/dL) from a nonazotemic baseline. Trauma severity, Animal Trauma Triage (ATT) score, survival, age, and species were compared between groups with and without AKI. Twenty-eight of 387 (7.24%) cases (23/167 [13.8% cats]; 5/220 [2.3% dogs]) had AKI on presentation. Cats were more likely to present with AKI than dogs (odds ratio: 4.95; 95% confidence interval, 2.36–10.8; P < 0.0001). Nine of 17 (52.9%) azotemic AKI patients in which serial creatinine concentrations were available had fluid-responsive AKI. HAAKI was documented in seven of 105 patients (6.67%). Median ATT score on presentation was higher in azotemic AKI than non-AKI cases (P = 0.02). Twenty-two of 28 (78.6%) azotemic AKI cases, three of seven (42.9%) HAAKI cases, and 316 of 359 (89.8%) non-AKI cases survived.

Conclusions

AKI occurs in canine and feline trauma and appears associated with higher trauma severity. Its impact on survival requires further investigation.

Abstract Image

查看原文本刊更多论文

小动物创伤患者急性肾损伤患病率及其与严重程度和预后的关系：387例（2017-2021）。

目的：描述犬和猫外伤中急性肾损伤（AKI）的患病率，并确定AKI与外伤严重程度、结局、种类和其他因素之间的关系。设计：分析一家医院在2017年4月至2021年2月期间提交给创伤兽医委员会登记的病例，这些病例在创伤后6小时内测量了血肌酐浓度。环境：英国大学教学医院。动物：共220例犬类和167例猫类外伤患者。测量和主要结果：Azotemic AKI定义为肌酐浓度> 140µmol/L (1.58 mg/dL)，并根据国际肾脏利益协会的液体反应性进行亚组。医院获得性AKI （HAAKI）定义为肌酐浓度从非氮化基线连续升高≥26.4µmol/L（≥0.3 mg/dL）。创伤严重程度、动物创伤分诊（ATT）评分、生存率、年龄和物种在有和没有AKI组之间进行比较。387例中28例（7.24%）（23/167例（13.8%）猫）；5/220（2.3%的狗）出现AKI。猫比狗更容易出现AKI(优势比：4.95；95%置信区间为2.36-10.8；P < 0.0001)。17例可获得连续肌酐浓度的azotemic AKI患者中有9例（52.9%）为液体反应性AKI。105例患者中有7例（6.67%）发生HAAKI。azotic AKI患者的平均ATT评分高于非AKI患者（P = 0.02）。28例azotemic AKI中有22例（78.6%）存活，7例HAAKI中有3例（42.9%）存活，359例非AKI中有316例（89.8%）存活。结论：AKI发生在犬和猫的创伤中，并且与较高的创伤严重程度相关。它对生存的影响需要进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.