Risk of age-related macular degeneration in late-onset atopic dermatitis: A multi-database cohort analysis.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-28 DOI:10.1097/IAE.0000000000004634

Tai-Li Chen, Hou-Ren Tsai, Wei-Chuan Chang, Jing-Wun Lu, Yi-Ju Chen, Yuan-Chieh Lee, Chen-Yi Wu

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引用次数: 0

Abstract

Purpose: To explore the relationship between atopic dermatitis (AD) and the risk of developing age-related macular degeneration (AMD).

Methods: This retrospective cohort study utilized data from two large databases: the US-based TriNetX Research Network (46,018 patients with AD aged ≥ 50 years, spanning 2005-2021) and Taiwan's National Health Insurance Research Database (NHIRD; 9,513 patients with AD aged ≥ 50 years, spanning 2003-2017). The main outcome was the incidence of AMD. The Cox regression analysis was used to calculate hazard ratios (HRs) for AMD. Additional analyses examined the risk of dry and wet AMD, with stratified assessments based on age, sex, ethnicity, race, and AD activity.

Results: Adults with AD exhibited a significantly elevated risk of developing AMD in both the TriNetX cohort (HR 1.97; 95% CI 1.78-2.19) and the NHIRD cohort (HR 1.25; 95% CI 1.11-1.41). Individual outcome analyses confirmed a heightened risk for both dry and wet AMD associated with AD. This increased risk was consistent across various groups stratified by demographic factors and AD activity.

Conclusions: AD in adulthood is linked to a greater likelihood of developing AMD. These findings underscore the importance of regular funduscopic evaluations and proactive management of AMD in patients with AD.

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迟发性特应性皮炎中年龄相关性黄斑变性的风险：多数据库队列分析。

目的：探讨特应性皮炎（AD）与老年性黄斑变性（AMD）发病风险的关系。9513例年龄≥50岁的AD患者，涵盖2003-2017年)。主要观察指标为AMD的发生率。采用Cox回归分析计算AMD的风险比（hr）。另外的分析检查了干性和湿性AMD的风险，并根据年龄、性别、种族、种族和AD活动进行了分层评估。结果：在TriNetX队列中，成年AD患者发生AMD的风险显著升高(HR 1.97；95% CI 1.78-2.19)和NHIRD队列(HR 1.25；95% ci 1.11-1.41)。个体结果分析证实干性和湿性AMD与AD相关的风险增加。这种增加的风险在按人口因素和AD活动分层的不同人群中是一致的。结论：成年期AD与发生AMD的可能性较大有关。这些发现强调了定期眼底评估和主动管理AD患者AMD的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.