Response time, amplitude, and neural auditory maintenance in individuals with tinnitus: a comparative study.

IF 0.8 Q4 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

CoDAS Pub Date : 2025-07-28 eCollection Date: 2025-01-01 DOI:10.1590/2317-1782/e20240211pt

Christine Grellmann Schumacher, Helinton Goulart Moreira, Denis Altieri de Oliveira Moraes, Larianny Rutzen Lazzari, Michele Vargas Garcia, Dayane Domeneghini Didoné

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Abstract

Purpose: To verify and compare the response time, amplitude, and neural auditory maintenance of the central auditory pathway in subjects with and without tinnitus disorder.

Methods: This is an analytical, cross-sectional, and quantitative study approved by the Research Ethics Committee. The responses of Long Latency Auditory Evoked Potentials (LLAEP) with verbal stimuli were compared between 16 subjects with tinnitus disorder (Study Group - SG) and 12 subjects without tinnitus (Control Group - CG). The neural response time was evaluated by the latency of the P1, N1, P2, N2, and P300 potentials. The amplitude of these potentials was also analyzed. Neural response maintenance was verified through the duration values of the P300 component. The results were compared between the groups, considering a significance level of 5%.

Results: In the comparison between the groups regarding the latency and amplitude values of the cortical potentials (P1, N1, P2, and N2), no statistically significant differences were observed (p>0.05). However, concerning the latency, amplitude, and duration of the P300 component between the groups, a statistically significant difference was observed for the latency variable, which was greater for individuals with tinnitus disorder (p<0.05).

Conclusion: Individuals with tinnitus disorder have a longer neural response time for the P300 component, suggesting disorganization in central auditory processing.

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耳鸣患者的反应时间、振幅和神经听觉维持：一项比较研究。

目的：验证和比较有耳鸣障碍和无耳鸣障碍受试者中枢听觉通路的反应时间、振幅和神经听觉维持。方法：这是一项经研究伦理委员会批准的分析性、横断面性和定量研究。比较了16例耳鸣障碍患者（研究组- SG）和12例非耳鸣患者（对照组- CG）的长潜伏期听觉诱发电位（LLAEP）对言语刺激的反应。通过P1、N1、P2、N2和P300电位的潜伏期评估神经反应时间。对这些电位的振幅也进行了分析。通过P300分量的持续时间值验证神经反应维持。将两组结果进行比较，考虑显著性水平为5%。结果：各组间皮质电位（P1、N1、P2、N2）潜伏期及振幅值比较，差异无统计学意义（p>0.05）。然而，在P300分量的潜伏期、振幅和持续时间方面，两组间的潜伏期变量差异有统计学意义，耳鸣障碍个体的潜伏期差异更大(结论：耳鸣障碍个体对P300分量的神经反应时间更长，提示中枢听觉加工紊乱。

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