The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design.

IF 4.6 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2025-07-18 DOI:10.3390/molecules30143009

Manuel Novás, Maria J Matos

引用次数: 0

Abstract

One of the key strategies in drug design involves modifying molecular scaffolds with specific chemical groups, or side chains, to enhance biological and physicochemical properties. These modifications can strengthen interactions with biological targets or improve pharmacokinetic and physicochemical characteristics, factors that are critical in transforming a compound into a viable drug candidate. In this overview, we focus on the presence of trifluoromethyl and trifluoromethoxy groups on different molecules, highlighting their relevance and impact in medicinal chemistry. The discussion and future perspectives in the field are based on a comprehensive review of current literature, with data sourced mainly from SciFinder and PubMed.

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三氟甲基和三氟甲氧基在药物化学中的作用：对药物设计的影响。

药物设计的关键策略之一是用特定的化学基团或侧链修饰分子支架，以增强生物和物理化学性质。这些修饰可以加强与生物靶点的相互作用或改善药代动力学和物理化学特性，这些因素是将化合物转化为可行的候选药物的关键因素。在这篇综述中，我们重点介绍了三氟甲基和三氟甲氧基在不同分子上的存在，强调了它们在药物化学中的相关性和影响。该领域的讨论和未来展望是基于对当前文献的全面回顾，数据主要来自SciFinder和PubMed。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.