Ameliorative Effect of Heat-Killed Lactiplantibacillus plantarum Q1 (LPQ1) on Lipid Accumulation: Integration of Network Pharmacology with In Vitro and In Vivo Experiments.
IF 3.1 4区 生物学Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Young-Jin Choi, Nishala Erandi Wedamulla, Seok-Hee Kim, Qun Zhang, Duseong Kim, Ji-Won Song, Seunghun Lee, Haeyoung Lee, Jeung Hee An, Ji Young Hwang, Eun-Kyung Kim
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引用次数: 0
Abstract
Lipid metabolism disorders are expanding at an alarming rate worldwide pressuring the entire healthcare system. Therefore, exploring effective therapeutic treatments for lipid metabolism disorders is a hot spot in research. The therapeutic effects of paraprobiotics on obesity are still not fully explored through the integration of network pharmacology analysis with in vitro and in vivo experiments to confirm their beneficial effect. Therefore, the current study aimed to investigate the ameliorative effect of heat-killed Lactiplantibacillus plantarum Q1 (LPQ1) on lipid accumulation through the integration of network pharmacology analysis with in vitro and in vivo experiments. Findings of network pharmacology analysis conform with in vitro and in vivo experiments, revealing that the modulating effect of LPQ1 on lipid metabolism was effective through the regulation of PPAR-γ and TNF-α expression. Therefore, LPQ1 can be promoted as an effective therapeutic agent against lipid metabolism disorders owing to its modulatory effect on hepatic lipid metabolism and inflammation.
脂质代谢紊乱正以惊人的速度在全球范围内扩大,给整个医疗保健系统带来压力。因此,探索脂质代谢紊乱的有效治疗方法是目前研究的热点。通过网络药理学分析和体内外实验相结合的方法来证实其有益作用,目前还没有充分探索副益生菌对肥胖的治疗作用。因此,本研究旨在通过网络药理学分析与体内外实验相结合的方法,探讨热杀植物乳杆菌Q1 (Lactiplantibacillus plantarum Q1, LPQ1)对脂质积累的改善作用。网络药理学分析结果与体外和体内实验结果一致,表明LPQ1通过调控PPAR-γ和TNF-α表达对脂质代谢的调节作用是有效的。因此,由于LPQ1对肝脏脂质代谢和炎症的调节作用,可以作为一种有效的治疗脂质代谢紊乱的药物。
期刊介绍:
The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.