A M K Chan, J R Coates, G C Johnson, H N Snyman, D W Silversides
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引用次数: 0
Abstract
Canine degenerative myelopathy (DM) has been associated with mutations in the superoxide dismutase 1 gene (SOD1). Although the SOD1:c.118G>A mutation has been identified in Boston terriers and French bulldogs, no histological-confirmed degenerative myelopathy has been reported in either breed. An 8-year-old male neutered Boston terrier-French bulldog mixed breed dog was presented with T3 to L3 myelopathy. Magnetic resonance imaging (MRI) of the spinal cord and cerebrospinal fluid analysis were unremarkable. DNA testing revealed homozygosity for the SOD1:c.118G>A mutation. Despite supportive treatment, the dog continued to progress over 37 months. Post mortem full spine MRI study found severe spinal cord and epaxial muscle atrophy. The diagnosis of DM was confirmed by histopathology and positive immunohistochemical staining with anti-SOD1 antibodies. This case report documents the clinical and imaging progression of DM in a Boston terrier-French bulldog mixed breed.
犬退行性脊髓病（DM）与超氧化物歧化酶1基因（SOD1）突变有关。虽然SOD1:c。在波士顿梗犬和法国斗牛犬中发现了一种突变，在这两个品种中都没有组织学证实的退行性脊髓病的报道。一只8岁雄性绝育波士顿梗犬-法国斗牛犬混合品种犬表现为T3至L3脊髓病。脊髓核磁共振（MRI）及脑脊液分析无明显差异。DNA检测显示SOD1:c具有纯合性。118 g > A突变。尽管进行了支持性治疗，但这只狗在37个月的时间里继续进步。死后全脊柱MRI检查发现严重的脊髓和外轴肌萎缩。经组织病理学和抗sod1抗体免疫组化染色阳性证实为DM。本病例报告记录了波士顿梗-法国斗牛犬混合品种DM的临床和影像学进展。
期刊介绍：
Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery.
In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world.
The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher.
The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association
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