From the perspective of dynamic changes in BMI: the relationship between BMI trajectories and dysglycemia, all-cause mortality.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-07-29 DOI:10.1186/s13098-025-01848-9

Buyu Guo, Yichen Yang, Na Wang, Yue Zhang, Caihong Jiao, Li Wang, Yanan Yan, Songbo Fu

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引用次数: 0

Abstract

Objectives: The aim was to explore the body mass index (BMI) trajectory over dynamic time and its relationship with the dysglycemia (including Type 2 Diabetes Mellitus and prediabetes), all-cause mortality, and insulin resistance.

Methods: The latent category trajectory model (LCTM) is used to identify the BMI trajectories. Logistic and Cox regression were fitted to assess the correlation between BMI trajectories/weight changes and Type 2 Diabetes Mellitus (T2DM)/prediabetes. Using linear regression to evaluate the correlation between the two and insulin resistance. Mediating role of inflammation was evaluated.

Results: Four BMI trajectories were identified, including "stable" (74.32%), "light increase" (17.18%), "rapid increase" (2.82%), and "increase-to-decrease" (5.67%). Compared to stable trajectories, participants with slight increase or increase-to-decrease trajectories had higher risks of T2DM, while participats with a slight increase or rapid increase trajectory had a higher probability of developing prediabetes. Early weight changes such as decrease, increase, overweight, or obesity were associated with higher T2DM, while recent weight changes like decrease or obesity-stable only impacted T2DM prevalence, and there were no significant associations for prediabetes.

Conclusion: The findings underscore the critical impact of BMI trajectories and early/recent weight changes on T2DM and mortality risk.

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从BMI动态变化的角度：BMI轨迹与血糖异常、全因死亡率的关系。

目的：探讨动态时间内的身体质量指数（BMI）轨迹及其与血糖异常（包括2型糖尿病和前驱糖尿病）、全因死亡率和胰岛素抵抗的关系。方法：采用潜在类别轨迹模型（LCTM）识别BMI轨迹。采用Logistic回归和Cox回归评估BMI轨迹/体重变化与2型糖尿病(T2DM)/前驱糖尿病之间的相关性。采用线性回归评价两者与胰岛素抵抗的相关性。评价炎症的介导作用。结果：确定了4种BMI轨迹，分别为“稳定”（74.32%）、“轻度上升”（17.18%）、“快速上升”（2.82%）和“由增到降”（5.67%）。与稳定的轨迹相比，轻度增加或增加到减少轨迹的参与者患T2DM的风险更高，而轻度增加或快速增加轨迹的参与者患前驱糖尿病的可能性更高。早期体重变化如减少、增加、超重或肥胖与较高的T2DM有关，而最近的体重变化如减少或肥胖稳定只影响T2DM的患病率，与前驱糖尿病没有显著的关联。结论：研究结果强调了BMI轨迹和早期/近期体重变化对2型糖尿病和死亡风险的重要影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.