Microfluidics-Based Polymeric Micro/Nanocarriers for Drug Delivery in Liver Cancer Treatment: Recent Advances, Outlooks, and Progress.

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Mahboobeh Ebrahimi Varkiani, Maryam Jadid Tavaf, Aliakbar Ebrahimiverkiani, Seyed Morteza Naghib
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Abstract

Microfluidics-based polymers are transforming drug delivery systems for liver cancer treatment as they enable precise synthesis of nano- and microparticles suitable for targeted therapy. The manufacture of programmable nanoparticles and tunable sizes is made possible by microfluidic platforms, which are essential for improving the effectiveness of medication administration. A wide range of therapeutic chemicals, including hydrophobic medications like doxorubicin, can be encapsulated in these systems to target liver cancers while reducing systemic toxicity effectively. It has also been demonstrated that combining natural hydrogels and droplet microfluidics can create multicellular tumor spheroids that resemble the tumor microenvironment more closely. This methodology improves screening and drug efficacy research and offers a strong foundation for assessing treatment outcomes. This research also explores novel uses of microfluidic technologies to develop intelligent drug delivery devices that respond to particular stimuli and release medication at the tumor site. It also investigated how artificial cell assemblies made with microfluidics can open new possibilities for individualized cancer treatment. To sum up, microfluidic-based polymers offer advanced tools for developing tailored and efficient drug delivery systems that can enhance patient outcomes, and represent a significant advancement in the treatment of liver cancer. The review paper discusses challenges in liver cancer treatment, including high drug clearance rates, low concentrations, and multidrug resistance. It suggests microfluidic technology can improve drug delivery systems by creating controlled particles and responding to tumor conditions. This could revolutionize liver cancer therapies, enabling better drug testing and treatment prediction, as well as designing tailored therapies.

基于微流体的高分子微/纳米药物载体在肝癌治疗中的应用:最新进展、展望和进展。
基于微流体的聚合物正在改变肝癌治疗的药物输送系统,因为它们能够精确合成适合靶向治疗的纳米和微粒。微流控平台使可编程纳米颗粒和可调尺寸的制造成为可能,这对于提高药物管理的有效性至关重要。广泛的治疗化学物质,包括像阿霉素这样的疏水药物,可以被封装在这些系统中,以靶向肝癌,同时有效地降低全身毒性。研究还表明,将天然水凝胶与微流控液滴相结合,可以创造出更接近肿瘤微环境的多细胞肿瘤球体。这种方法改善了筛查和药物疗效研究,并为评估治疗结果提供了坚实的基础。本研究还探索了微流体技术的新用途,以开发智能药物输送装置,对特定的刺激做出反应,并在肿瘤部位释放药物。它还研究了用微流体制造的人造细胞组件如何为个体化癌症治疗开辟新的可能性。总之,基于微流体的聚合物为开发量身定制的高效药物输送系统提供了先进的工具,可以提高患者的治疗效果,并代表了肝癌治疗的重大进步。本文讨论了肝癌治疗面临的挑战,包括高药物清除率、低药物浓度和多药耐药。该研究表明,微流体技术可以通过制造可控颗粒和对肿瘤状况做出反应来改善药物输送系统。这可能会彻底改变肝癌治疗,使更好的药物测试和治疗预测,以及设计量身定制的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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