Hospital-cyclotrons production of high-purity ¹⁵⁵Tb via ¹⁵⁵Gd(p,n).

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-07-17 DOI:10.1016/j.apradiso.2025.112026

Francesca Barbaro, Luciano Canton, Nikolay Uzunov, Laura De Nardo, Laura Meléndez-Alafort

引用次数: 0

Abstract

Terbium radionuclides are gaining prominence in theranostics, with ¹⁵⁵Tb emerging as promising SPECT imaging agent due to its γ emissions (87 keV, 32%; 105 keV, 25%) and favorable half-life (T_1/2=5.32 days), allowing extended biodistribution monitoring. However, efficient production via hospital cyclotrons is challenging, particularly in reducing ¹⁵⁶Tb contamination, which affects image quality and increases patient dose. This study investigates the ¹⁵⁵Gd(p,n)¹⁵⁵Tb reaction, highlighting the importance of ¹⁵⁵Gd target enrichment.

查看原文本刊更多论文

利用155Gd（p,n）制备高纯度155Tb的医院回旋加速器。

铽放射性核素在治疗学中越来越突出，155Tb由于其γ辐射(87 keV, 32%；105 keV, 25%)和有利的半衰期（T1/2=5.32天），允许延长生物分布监测。然而，通过医院回旋加速器进行高效生产具有挑战性，特别是在减少156Tb污染方面，这会影响图像质量并增加患者剂量。本研究考察了155Gd(p,n)155Tb反应，强调了155Gd靶富集的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.

Hospital-cyclotrons production of high-purity 155Tb via 155Gd(p,n).

Abstract

Hospital-cyclotrons production of high-purity ¹⁵⁵Tb via ¹⁵⁵Gd(p,n).