The metabolic syndrome in ambulatory people with post-polio syndrome, Charcot-Marie-Tooth disease and other neuromuscular diseases.

IF 2.4 4区医学 Q1 REHABILITATION

American Journal of Physical Medicine & Rehabilitation Pub Date : 2025-07-29 DOI:10.1097/PHM.0000000000002800

Eric Lukas Voorn, Sander Oorschot, Nicolette Janine Wierdsma, Maarten René Soeters, Fieke Sophia Koopman, Annerieke Ceciel van Groenestijn

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引用次数: 0

Abstract

Objective: The metabolic syndrome (MetS) is a growing health issue. This study evaluated the prevalence of MetS, and individual MetS risk factors, in people with different neuromuscular diseases (NMD).

Design: We used baseline data of a randomized controlled trial on the efficacy of a physical activity program in NMD. MetS was defined as the presence of at least 3 out of 5 risk factors of the revised National Cholesterol Education Program Adult Treatment Panel III.

Results: The 84 participants (50 female, median age = 63 years, IQR = 48, 68 years) were diagnosed with post-polio syndrome (PPS, n = 22), Charcot-Marie-Tooth disease (CMT, n = 37) or other NMD (n = 25). MetS was present in 18 participants (21%). The most common risk factors were hypertension (56%), central obesity (49%) and increased fasting blood glucose (33%). Logistic regression results showed that, adjusted for age and muscle strength as confounders, participants with CMT (Exp(B) = 0.107, 95%CI: 0.019-0.609) and other NMD (Exp(B) = 0.039, 95%CI: 0.004-0.390) had significantly lower odds of MetS compared with PPS.

Conclusion: The MetS prevalence that we found is comparable to the general Dutch population. However, a focus on the prevention of MetS in neuromuscular rehabilitation is warranted, as certain NMD subgroups may be at increased risk of developing MetS.

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脊髓灰质炎后综合征、腓骨肌萎缩症和其他神经肌肉疾病患者的代谢综合征。

目的：代谢综合征（MetS）是一个日益严重的健康问题。本研究评估了不同神经肌肉疾病（NMD）患者的MetS患病率和个体MetS危险因素。设计：我们使用了一项随机对照试验的基线数据，研究体育活动计划对NMD的疗效。根据修订后的国家胆固醇教育计划成人治疗小组III， MetS被定义为至少存在5个危险因素中的3个。结果：84名参与者（女性50名，中位年龄63岁，IQR = 48, 68岁）被诊断为脊髓灰质炎后综合征（PPS, n = 22）， Charcot-Marie-Tooth病（CMT, n = 37）或其他NMD （n = 25）。18名参与者（21%）出现MetS。最常见的危险因素是高血压（56%）、中心性肥胖（49%）和空腹血糖升高（33%）。Logistic回归结果显示，将年龄和肌肉力量作为混杂因素进行调整后，CMT （Exp(B) = 0.107, 95%CI: 0.019-0.609）和其他NMD （Exp(B) = 0.039, 95%CI: 0.004-0.390）的参与者与PPS相比，MetS的几率显着降低。结论：我们发现的met患病率与荷兰一般人群相当。然而，神经肌肉康复的重点是预防MetS是有必要的，因为某些NMD亚群可能会增加发生MetS的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Physical Medicine & Rehabilitation 医学-康复医学

CiteScore

4.60

自引率

6.70%

发文量

423

审稿时长

1 months

期刊介绍： American Journal of Physical Medicine & Rehabilitation focuses on the practice, research and educational aspects of physical medicine and rehabilitation. Monthly issues keep physiatrists up-to-date on the optimal functional restoration of patients with disabilities, physical treatment of neuromuscular impairments, the development of new rehabilitative technologies, and the use of electrodiagnostic studies. The Journal publishes cutting-edge basic and clinical research, clinical case reports and in-depth topical reviews of interest to rehabilitation professionals. Topics include prevention, diagnosis, treatment, and rehabilitation of musculoskeletal conditions, brain injury, spinal cord injury, cardiopulmonary disease, trauma, acute and chronic pain, amputation, prosthetics and orthotics, mobility, gait, and pediatrics as well as areas related to education and administration. Other important areas of interest include cancer rehabilitation, aging, and exercise. The Journal has recently published a series of articles on the topic of outcomes research. This well-established journal is the official scholarly publication of the Association of Academic Physiatrists (AAP).