Prevalence Estimates and Distribution of Entamoeba histolytica and Entamoeba dispar Infections in Several Regions of Thailand: A Systematic Review and Meta-Analysis.

IF 1.6 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-07-29 Print Date: 2025-10-01 DOI:10.4269/ajtmh.25-0188

Manas Kotepui, Aongart Mahittikorn, Frederick R Masangkay, Supaluk Popruk

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引用次数: 0

Abstract

Entamoeba histolytica (E. histolytica) causes amebiasis, which is a major health concern in tropical regions, including Thailand. This systematic review and meta-analysis aimed to assess the prevalence, distribution, and epidemiological trends of E. histolytica and morphologically identical species infections in Thailand to inform public health strategies. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, this study was registered in PROSPERO (CRD42025636219). A comprehensive search in the PubMed, EMBASE, Journal@Ovid, Nursing & Allied Health Premium, Scopus, and the Thai Journal Citation Index databases was conducted. Two authors independently screened the studies, extracted data, and assessed quality using the Joanna Briggs Institute critical appraisal tool. The meta-analysis was conducted by using logit transformation and random effects models, with heterogeneity assessed via Q tests, I2 statistics, and meta-regression. Publication bias was examined by using funnel plots and Egger's test. Of 899 records, 44 studies with 36,720 participants met the inclusion criteria. The overall prevalence of E. histolytica and infections with morphologically identical species in Thailand was 1.30% (95% CI: 0.89-1.89%) with high heterogeneity (I2 = 92.0%). The highest prevalence was in western (2.86%) and northeastern Thailand (1.93%). High-risk groups, including dam personnel (10.28%), individuals with intellectual disabilities (7.05%), and orphaned children (3.95%), exhibited elevated prevalence levels. Molecular methods resulted in the detection of higher rates (5.12%) than traditional techniques. Despite low overall prevalence, regional variations and high-risk populations highlight the need for sensitive diagnostics, targeted interventions, and continuous surveillance to reduce the burden of amebiasis in Thailand.

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泰国几个地区溶组织内阿米巴和异速内阿米巴感染的患病率估计和分布：一项系统综述和荟萃分析。

溶组织内阿米巴引起阿米巴病，这是包括泰国在内的热带地区的一个主要卫生问题。本系统综述和荟萃分析旨在评估泰国溶组织芽孢杆菌和形态相同物种感染的患病率、分布和流行病学趋势，为公共卫生策略提供信息。根据系统评价和荟萃分析指南的首选报告项目，本研究已在PROSPERO注册（CRD42025636219）。在PubMed、EMBASE、Journal@Ovid、Nursing & Allied Health Premium、Scopus和Thai Journal Citation Index数据库中进行了全面的检索。两位作者独立筛选研究，提取数据，并使用乔安娜布里格斯研究所的关键评估工具评估质量。meta分析采用logit变换和随机效应模型，通过Q检验、I2统计量和meta回归评估异质性。采用漏斗图和Egger检验检验发表偏倚。在899项记录中，有44项研究有36720名参与者符合纳入标准。泰国溶组织芽胞杆菌和形态相同物种感染的总体患病率为1.30% (95% CI: 0.89-1.89%)，异质性高（I2 = 92.0%）。泰国西部（2.86%）和东北部（1.93%）患病率最高。高发人群包括大坝人员（10.28%）、智障人士（7.05%）和孤儿（3.95%）。分子方法的检出率（5.12%）高于传统方法。尽管总体患病率较低，但区域差异和高危人群突出表明，需要进行敏感的诊断、有针对性的干预措施和持续监测，以减轻泰国阿米巴病的负担。

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来源期刊

American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.20

自引率

3.00%

发文量

508

审稿时长

3 months

期刊介绍： The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries