Cavitation-vibration coupling mechanism in ultrasonic guidewire vascular ablation.

IF 9.7 1区 化学 Q1 ACOUSTICS
Ultrasonics Sonochemistry Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI:10.1016/j.ultsonch.2025.107474
Guang Yao, Maozhong Wu, Jianhua Lai, Youcheng Lv, Lijuan Zheng, Chengyong Wang
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引用次数: 0

Abstract

Effective treatment of diverse vascular occlusions requires precise energy delivery and tissue-specific ablation strategies. This study systematically investigates the coupled mechanical vibration and cavitation mechanisms of a novel flexible ultrasonic guidewire during ablation of calcified, lipid-rich, and thrombotic occlusion mimics. Integrating numerical simulations and experimental validation, this work elucidates the dynamic interplay between ultrasonic parameters and tissue-specific ablation outcomes. For calcified mimics, mechanical vibrational impact is the dominant ablation mechanism, achieving substantial material removal primarily through fracture. Lipid-rich tissue ablation is driven by emulsification via cavitation microjets and acoustic streaming, generating microparticles with sizes of 10-250 μm, controllable by ultrasonic power. Thrombus ablation involves initial penetration followed by erythrocyte lysis, primarily mediated by transient cavitation. Crucially, guidewire bending significantly attenuates tip vibration amplitude, resulting in a reduction of 14.3-30.9 %, with titanium alloy exhibiting superior energy transmission stability under curvature compared to nickel-titanium. These findings highlight distinct, tissue-dependent ablation paradigms: mechanical fragmentation for hard tissues compared to cavitation and streaming induced emulsification or lysis for soft tissues. This mechanistic understanding is foundational for designing adaptive ultrasonic guidewires capable of adjusting energy delivery modes based on real time feedback of tissue characteristics, thereby enhancing the precision and efficacy of endovascular interventions.

超声导丝血管消融中的空化-振动耦合机理。
各种血管闭塞的有效治疗需要精确的能量输送和组织特异性消融策略。本研究系统地研究了一种新型柔性超声导丝在钙化、富脂和血栓闭塞模拟物消融过程中的耦合机械振动和空化机制。结合数值模拟和实验验证,这项工作阐明了超声参数与组织特异性消融结果之间的动态相互作用。对于钙化模拟材料,机械振动冲击是主要的烧蚀机制,主要通过断裂实现大量材料的去除。富脂组织消融由空化微射流和声流的乳化驱动,产生10 ~ 250 μm大小的微颗粒,超声功率可控制。血栓消融包括最初的穿透,随后是红细胞溶解,主要由短暂空化介导。最重要的是,导丝弯曲显著降低了尖端振动幅值,导致振动幅值降低14.3- 30.9%,与镍钛相比,钛合金在曲率下表现出更好的能量传输稳定性。这些发现突出了不同的、组织相关的消融模式:硬组织的机械碎裂与软组织的空化和流诱导的乳化或溶解相比。这种机制的理解是设计自适应超声导丝的基础,该导丝能够根据组织特征的实时反馈调整能量传递模式,从而提高血管内介入的精度和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ultrasonics Sonochemistry
Ultrasonics Sonochemistry 化学-化学综合
CiteScore
15.80
自引率
11.90%
发文量
361
审稿时长
59 days
期刊介绍: Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.
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