Supplementing advanced chelated trace minerals beyond recommended inorganic levels improve growth performance and physiological stress responses in broiler chickens under heat stress

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-07-29 DOI:10.1016/j.jtemb.2025.127708

Taher Mohammadizad , Kamran Taherpour , Hossein Ali Ghasemi , Hassan Shirzadi , Fatemeh Tavakolinasab , Mohammad Hassan Nazaran

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引用次数: 0

Abstract

Background

Organic trace minerals (TM) offer potential benefits for poultry health and productivity; however, their effectiveness under heat stress (HS) conditions is not well characterized. This study aimed to evaluate the effects of supplementing broiler diets with an advanced chelate-based trace mineral complex (ATMC) under cyclic HS conditions.

Methods

A total of 600 one-day-old Ross 308 broilers were randomly assigned to five dietary treatment groups for a 42-day study: (1) TC, which received a basal diet supplemented with the commercial levels of inorganic trace minerals (ITM) under thermoneutral conditions; (2) HSC, which consisted of a basal diet with the commercial ITM levels under heat stress; (3) ITM+ATMC12.5; (4) ITM+ATMC25, where diets were supplemented with 12.5 % and 25 % additional TM from ATMC, respectively, under HS; and (5) ITM125, which included a diet with 125 % of the recommended ITM levels under HS.

Results

The ITM+ATMC25 group exhibited significantly higher weight gain, European Production Efficiency Index, serum T₄ concentration, and duodenal villus height compared to the HSC group, with results comparable to the TC group. Additionally, feed conversion ratio, mortality rate, abdominal fat, liver weight, heterophil-to-lymphocyte ratio, alkaline phosphatase activity, and corticosterone concentration were lower in the TC and ITM+ATMC25 groups compared to the HSC group. The expression levels of heat shock protein (HSP) 70 in the liver and hypothalamus were lower in the TC and ITM+ATMC25 groups, indicating improved stress resilience. Furthermore, hepatic HSP90 expression was downregulated in the TC, ITM+ATMC12.5, and ITM+ATMC25 groups compared to the HSC group.

Conclusion

The results indicate that adding 25 % more TM provided by ATMC than the recommended ITM levels can positively affect growth, intestinal structure, and stress-related physiological responses in broilers exposed to HS.

查看原文本刊更多论文

在热应激条件下，添加超过推荐无机水平的高级螯合微量矿物质可改善肉鸡的生长性能和生理应激反应

有机微量矿物质（TM）对家禽健康和生产力具有潜在的益处；然而，它们在热应力（HS）条件下的有效性尚未得到很好的表征。本研究旨在评价在循环HS条件下，在肉鸡饲粮中添加高级螯合基微量矿物质复合物（ATMC）的效果。方法选取600只1日龄罗斯308肉鸡，随机分为5个饲粮处理组，进行为期42 d的试验：(1)热中性条件下，TC组饲喂在基础饲粮中添加商业水平无机微量矿物质（ITM）的试验饲粮；(2) HSC，即热应激条件下的基础饲粮和商业ITM水平；(3) ITM + ATMC12.5;(4) ITM+ATMC25， HS组饲粮中分别添加12.5 %和25 %的ATMC TM；(5) ITM125，其中饮食中ITM含量为HS下推荐水平的125 %。结果与HSC组相比，ITM+ATMC25组的增重、欧洲生产效率指数、血清T4浓度和十二指肠绒毛高度均显著高于HSC组，与TC组相当。此外，TC组和ITM+ATMC25组的饲料系数、死亡率、腹部脂肪、肝脏重量、异嗜淋巴细胞比、碱性磷酸酶活性和皮质酮浓度均低于HSC组。TC和ITM+ATMC25组小鼠肝脏和下丘脑热休克蛋白（HSP） 70表达水平较低，表明应激恢复能力增强。此外，与HSC组相比，TC组、ITM+ATMC12.5组和ITM+ATMC25组肝脏HSP90表达下调。结论ATMC提供的TM在推荐ITM水平基础上增加25 %对HS暴露肉鸡生长、肠道结构和应激相关生理反应有积极影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.