Childhood and adolescents’ cancer survival: Progress made and priorities for improvement. An Italian population-based study

IF 2.3 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-07-31 DOI:10.1016/j.canep.2025.102895

Camilla Calì , Rosalba Amodio , Sabrina Fabiano , Gemma Gatta , Milena Maria Maule , Viviana Perotti , Fabio Savoia , Marcella Sessa , Andrea Tittarelli , Walter Mazzucco , Fabrizio Stracci , Rosalia Ragusa , AIRTUM Working Group

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Abstract

Background

Population-based cancer registries are crucial to monitor health system performance, inform policy makers and allocate resources effectively. We updated Italian survival estimates for children and adolescents, analysing temporal and geographical differences to evaluate improvements.

Methods

Cases were from the Association of Italian Cancer Registries and codified according to the International Classification of Childhood Cancer, 3rd edition.

Thirty-one cancer registries provided 9142 incident cases (2013–2017) and 15 cancer registries contributed data for 12,447 incident cases (1998–2017) for trend analysis. We used the period approach to estimate survival in children (0–14 years) and adolescents (15–19 years) during the period 2013–2017. Survival was estimated by age, sex and geographical area of residence.

Results

Survival improved over time in both children and adolescents. Among children, significant progress was observed for acute myeloid leukaemia, non-Hodgkin lymphomas, ependymomas, Ewing sarcoma, and acute lymphoid leukaemia. For adolescents, notable improvements were found in non-Hodgkin lymphomas and skin melanomas. However, disparities emerged across Italy, with major differences observed for central nervous system neoplasms and osteosarcoma in children, as well as for acute lymphatic leukaemia and soft tissue sarcomas in adolescents.

Conclusion

Increased survival was observed in many Italian children and adolescents with tumours and differences emerged across Italian regions. We will investigate the reasons for these discrepancies in collaboration with clinicians.

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儿童和青少年癌症生存：取得的进展和需要改善的优先事项。一项基于意大利人口的研究

基于人群的癌症登记对于监测卫生系统绩效、为决策者提供信息和有效分配资源至关重要。我们更新了意大利儿童和青少年的生存估计，分析了时间和地理差异，以评估改善情况。方法病例来自意大利癌症登记协会，根据《国际儿童癌症分类》第3版编纂。31个癌症登记处提供了9142例病例（2013-2017年），15个癌症登记处提供了12447例病例（1998-2017年）的数据用于趋势分析。我们使用时期法估计2013-2017年期间儿童（0-14岁）和青少年（15-19岁）的生存率。生存率根据年龄、性别和居住的地理区域来估计。结果儿童和青少年的生存率随着时间的推移而提高。在儿童中，急性髓性白血病、非霍奇金淋巴瘤、室管膜瘤、尤文氏肉瘤和急性淋巴性白血病的进展显著。对于青少年，非霍奇金淋巴瘤和皮肤黑素瘤的治疗有显著改善。然而，意大利各地出现了差异，主要差异见于儿童的中枢神经系统肿瘤和骨肉瘤，以及青少年的急性淋巴白血病和软组织肉瘤。结论意大利许多儿童和青少年肿瘤患者的生存率均有所提高，但不同地区存在差异。我们将与临床医生合作调查这些差异的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.