Fast visualization of multiple trace antibiotics by modified Eu/Tb MOF test paper

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-07-28 DOI:10.1016/j.talanta.2025.128649

Fang Yuan, Dingfan Yan, Shuaibo Song, Jinbo Zhang, Zheng Chen, Jiahao Lu, Simin Wang, Tao Li

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Abstract

To address the current situation of the poor detection efficiency of multiple trace antibiotic contamination in the aqueous environment, we synthesized a modified lanthanide MOF material, Ln-MOF(NH₂)@R6G, for the rapid visual quantitation of trace norfloxacin (NOR), ciprofloxacin (CIP) and tetracycline (TC). By introducing the ligands of NH₂-BDC and R6G with abundant amino groups, the interaction of material with antibiotics was largely strengthened. Sensitive detection completed within 1 min with dramatically low detection limit of LOD_NOR = 16.56 nM, LOD_CIP = 6.14 nM, LOD_TC = 19.6 nM. Based on the visible color change to the naked eyes, we succeeded in loading the synthesized material onto the test paper, which realized semi-quantitative detection of antibiotics (concentration range of 10–100 μM) in actual water systems. Taking advantages of the significant difference of the NOR and CIP induced fluorescence color, as well as the non-interfering property with each other, we developed a data model for simultaneously visual quantifying NOR and CIP by the RGB-CIE variation maps in their coexisting actual system (recoveries 96.48 %–105.34 %, RSD 0.03 %–0.81 %). The result developed a promising portable visual analysis for the trace antibiotics in complex waters, and provided a novel strategy for in situ screening of environmental pollutants.

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改良Eu/Tb MOF试纸快速可视化多种微量抗生素

针对目前水环境中多种微量抗生素污染检测效率较差的现状，我们合成了一种修饰镧系MOF材料，mn -MOF(NH2)@R6G，用于痕量诺氟沙星（NOR）、环丙沙星（CIP）和四环素（TC）的快速目测定量。通过引入氨基丰富的NH2-BDC和R6G配体，材料与抗生素的相互作用大大增强。LODNOR = 16.56 nM, LODCIP = 6.14 nM, LODTC = 19.6 nM的检出限极低，在1 min内完成灵敏检测。基于肉眼可见的颜色变化，我们成功地将合成材料加载到试纸上，实现了实际水系中抗生素（浓度范围10-100 μM）的半定量检测。利用NOR和CIP诱导荧光颜色的显著差异和互不干扰的特点，建立了在其共存的实际体系中利用RGB-CIE变异图同时可视化定量NOR和CIP的数据模型（回收率为96.48% ~ 105.34%，RSD为0.03% ~ 0.81%）。该结果为复杂水体中痕量抗生素的便携式可视化分析提供了一种有前景的方法，并为环境污染物的原位筛选提供了一种新的策略。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.