Platelets in the regulation of glucose and lipid metabolism—functions beyond the maintenance of vascular integrity are being revealed

Abstract

Platelets, small anucleate blood cells, are essential not only for maintaining vascular integrity but also for broader systemic homeostasis. Traditionally recognized for their role in preventing hemorrhage following injury, recent research has revealed their involvement in a range of metabolic processes. Notably, platelets contribute to the regulation of insulin secretion, glucose blood levels, adipose tissue metabolism, and liver function. Furthermore, they have been implicated in the development of metabolic disorders, such as type 2 diabetes, obesity, and liver diseases. This review highlights the latest insights into how platelets influence key organs involved in systemic metabolic regulation.