Proliferative vitreoretinopathy and outer retinal folds in rhegmatogenous retinal detachment. Insights into retinal remodeling.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-07-24 DOI:10.1097/IAE.0000000000004631

Marzia Affatato, Angela Maria Castelluzzo, Giuseppe Rapino, Pasquale Cucciniello, Ciro Giugliano, Caterina Picotto, Giuseppe Campagna, Tommaso Rossi, Lucia Ziccardi, Roberto dell'Omo

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引用次数: 0

Abstract

Purpose: To evaluate the relationship between proliferative vitreoretinopathy (PVR) and outer retinal folds (ORFs) in eyes with rhegmatogenous retinal detachment (RRD).

Methods: Prospective cohort study. Patients with primary RRD operated with pars plana vitrectomy were studied postoperatively by using blue fundus autofluorescence and spectral-domain optical coherence tomography. Primary outcome was the influence of PVR severity on the incidence and height of ORFs at 1 month after surgery .

Results: The study included 171 eyes. One month after operation, ORFs were identified in 22% of the eyes with PVR A, 26.6% with PVR B, and 44.4% with PVR C. The mean height (± SD) of ORFs was 99.8 ± 18.3 µm, 138.3 ± 50.3 µm and 199.25 ± 200.0 µm in PVR A, B and C, respectively (P = 0.008). Variables associated with the presence of ORFs included PVR grade C (p = 0.004), presence of ERM (P = 0.004), and gas tamponade (P = 0.02). PVR grade C correlated with ORFs height ( P = 0.006).

Conclusion: PVR grade C is significantly associated with the incidence and height of ORFs at 1 month after surgery in eyes undergone PPV to repair RRD. Outer retinal folds may provide important insights about the process of retina remodeling occurring in eyes with RRD complicated by PVR C.

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孔源性视网膜脱离的增生性玻璃体视网膜病变和外视网膜褶皱。深入了解视网膜重塑。

目的：探讨孔源性视网膜脱离（RRD）眼增生性玻璃体视网膜病变（PVR）与视网膜外褶皱（orf）的关系。方法：前瞻性队列研究。采用蓝色眼底自体荧光和光谱域光学相干断层扫描对原发性RRD行玻璃体部切除术的患者进行术后研究。主要观察结果为术后1个月PVR严重程度对眼球外孔发生率和高度的影响。结果：本研究纳入171只眼。术后1个月，PVR A组、PVR B组和PVR C组分别有22%、26.6%和44.4%的眼睛发现orf。PVR A、B和C组orf的平均高度（±SD）分别为99.8±18.3µm、138.3±50.3µm和199.25±200.0µm （P = 0.008）。与orf存在相关的变量包括PVR C级（p = 0.004）、ERM的存在（p = 0.004）和气体填塞（p = 0.02）。PVR C级与orf高度相关（P = 0.006）。结论：采用PPV修复RRD的眼术后1个月，PVR C级与orf的发生率及高度有显著相关性。视网膜外折叠可能为RRD合并PVR - C的眼睛视网膜重塑过程提供重要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.