LC-MS Analysis of Bioactive Compounds in Cynodon dactylon: A Step Towards Therapeutic drug development.

Q2 Medicine

Clinica Terapeutica Pub Date : 2025-07-01 DOI:10.7417/CT.2025.5242

M Gokul, A K Nayanatara, R D Kini, R Sheryl

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引用次数: 0

Abstract

Purpose: Phytochemicals are naturally occurring bioactive compounds produced by plants as a defense against environmental stressors. Cynodon dactylon is a widely distributed medicinal plant known for its diverse pharmacological properties. The present study explores the bioactive compounds of the hydro-alcoholic extract of Cynodon dactylon.

Methods: The entire Cynodon dactylon plant was collected, authenticated, and extracted using a Soxhlet apparatus with a hydro-alcoholic solvent. Phytochemical analysis was conducted using Thin Layer Chromatography (TLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) was done to identify specific bioactive compounds.

Results: TLC analysis confirmed the presence of potent phyto-chemicals. LC-MS analysis revealed multiple bioactive compounds, including Harmine, which was identified for the first time in Cynodon dactylon.

Conclusion: The identification of multiple bioactive compounds in Cynodon dactylon, particularly Harmine, highlights its potential for neuroprotection and the treatment of neuropsychiatric disorders. Further in vivo and clinical studies are needed to validate these findings and explore the plant's therapeutic applications in neurological health.

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短爪蟹生物活性成分的LC-MS分析：迈向治疗药物开发的一步。

目的：植物化学物质是一种天然存在的生物活性化合物，由植物产生，作为对环境胁迫的防御。短爪蟹是一种广泛分布的药用植物，具有多种药理特性。本研究对短爪蟹水醇提取物的生物活性成分进行了研究。方法：采用索氏仪和水酒精溶剂提取全株Cynodon dactylon。采用薄层色谱（TLC）和液相色谱-质谱（LC-MS）进行植物化学分析，以确定特定的生物活性成分。结果：薄层色谱分析证实了有效的植物化学物质的存在。LC-MS分析发现了多种生物活性化合物，其中包括首次在Cynodon dactylon中鉴定到的hammine。结论：经鉴定，短爪蟹中含有多种生物活性成分，其中尤以毒碱为重要成分，具有神经保护作用和治疗神经精神疾病的潜力。需要进一步的体内和临床研究来验证这些发现，并探索该植物在神经健康方面的治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Terapeutica PHARMACOLOGY & PHARMACY-

CiteScore

2.50

自引率

0.00%

发文量

124

审稿时长

6-12 weeks

期刊介绍： La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.