Evaluating the Lowest Post-IVIG Body Temperature as a Predictor of Treatment Response in Kawasaki Disease.

IF 1.8 4区医学 Q2 HEALTH POLICY & SERVICES

Journal of Pediatric Health Care Pub Date : 2025-07-28 DOI:10.1016/j.pedhc.2025.06.001

Wan-Fu Hsu, Pi-Chang Lee, Ying-Hsiu Lin, Chun-Chieh Hu, Chen-Yu Fan, Der-Shiun Wang, Yen-Mei Lee, Mei-Jy Jeng

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引用次数: 0

Abstract

Introduction: Intravenous immunoglobulin (IVIG) is the standard therapy for Kawasaki disease (KD), reducing inflammation and coronary artery complications. However, some patients exhibit IVIG resistance. This study aimed to identify markers of IVIG efficacy in KD.

Methods: A retrospective analysis included KD patients treated with IVIG from January 2011 to September 2023. Patients were divided into IVIG-sensitive and IVIG-resistant groups. Data from those diagnosed before October 2022 formed the development dataset, while later cases comprised the validation dataset.

Results: Among 123 patients, 110 were IVIG-sensitive and 13 were IVIG-resistant. The lowest post-IVIG body temperature (BT) was significantly lower in the IVIG-sensitive group. A BT threshold of 36.05 °C showed sensitivity of 69.2% and specificity of 79.1%. Combining BT with pre-IVIG scoring systems improved specificity to 85.5%-93.6%.

Discussion: The lowest post-IVIG BT is a potential predictor of IVIG response, enhancing accuracy when combined with scoring systems.

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评估ivig后最低体温作为川崎病治疗反应的预测因子。

静脉注射免疫球蛋白（IVIG）是川崎病（KD）的标准治疗方法，可减少炎症和冠状动脉并发症。然而，一些患者表现出IVIG耐药性。本研究旨在确定IVIG在KD中疗效的标志物。方法：回顾性分析2011年1月至2023年9月接受IVIG治疗的KD患者。患者分为ivig敏感组和ivig耐药组。2022年10月之前诊断的病例数据构成了发展数据集，而之后的病例组成了验证数据集。结果：123例患者中，110例ivig敏感，13例ivig耐药。ivig敏感组ivig后最低体温（BT）明显降低。BT阈值为36.05°C，敏感性为69.2%，特异性为79.1%。BT联合ivig前评分系统可将特异性提高至85.5%-93.6%。讨论：IVIG后最低BT是IVIG反应的潜在预测指标，与评分系统结合使用可提高准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Health Care NURSING-PEDIATRICS

CiteScore

3.40

自引率

10.70%

发文量

140

审稿时长

24 days

期刊介绍： The Journal of Pediatric Health Care, the official journal of the National Association of Pediatric Nurse Practitioners, provides scholarly clinical information and research regarding primary, acute and specialty health care for children of newborn age through young adulthood within a family-centered context. The Journal disseminates multidisciplinary perspectives on evidence-based practice and emerging policy, advocacy and educational issues that are of importance to all healthcare professionals caring for children and their families.