The Role of Circular RNA in the Progression of Gliomas and Its Potential Clinical Applications.

IF 3.5 3区 生物学 Q1 BIOLOGY
Wen Wu, Menglei Xiong, Chen Jiang, Xinru Zhou, Yingjie Ma, Tao Wang, Shan He, Baicheng Ma
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引用次数: 0

Abstract

Circular RNAs (circRNAs) are single-stranded noncoding RNAs with a covalently closed loop structure. They are known for their stability, abundance, and highly conserved nature. Their expression is often specific to tissues or developmental stages. They interact with microRNAs (miRNAs) and RNA-binding proteins (RBPs) and they undergo N6-methyladenosine (m6A) modifications, further affecting gene transcription and translation. Increasing evidence over the past decades has revealed that dysregulated circRNA expression is associated with various neurological disorders, particularly the glioma, one of the most malignant tumors with a poor prognosis. Due to the presence of the blood-brain barrier (BBB) and drug resistance, conventional therapeutic approaches have shown limited efficacy. Recently, increasing attention has been directed toward precisely targeted therapies, with circRNAs emerging as promising molecules for cancer treatment. Studies indicate that circRNAs play a key role in glioma proliferation and metastasis. Substantial evidence indicates that exosomes can package circRNAs and facilitate their transport across the BBB into brain tissue, highlighting the potential of circRNAs as therapeutic targets for glioma. This review summarizes circRNAs' functional mechanisms, clinical application relevance, and current limitations. It offers future research directions in this evolving field, aiming to encourage further research on circRNAs' therapeutic applications and contribute to the development of novel glioma-treatment strategies.

环状RNA在胶质瘤进展中的作用及其潜在的临床应用。
环状rna (circRNAs)是具有共价闭环结构的单链非编码rna。它们以稳定、丰富和高度保守的性质而闻名。它们的表达通常与组织或发育阶段有关。它们与microRNAs (miRNAs)和rna结合蛋白(rbp)相互作用,并经过n6 -甲基腺苷(m6A)修饰,进一步影响基因转录和翻译。在过去的几十年里,越来越多的证据表明,circRNA表达失调与各种神经系统疾病有关,特别是胶质瘤,这是一种预后不良的恶性肿瘤。由于血脑屏障(BBB)的存在和耐药性,传统的治疗方法显示出有限的疗效。最近,人们越来越多地关注精确靶向治疗,环状rna成为治疗癌症的有希望的分子。研究表明,环状rna在胶质瘤的增殖和转移中起着关键作用。大量证据表明,外泌体可以包装环状rna并促进其通过血脑屏障运输到脑组织,这突出了环状rna作为胶质瘤治疗靶点的潜力。本文综述了circrna的功能机制、临床应用相关性以及目前的局限性。它为这一不断发展的领域提供了未来的研究方向,旨在鼓励进一步研究环状rna的治疗应用,并为开发新的胶质瘤治疗策略做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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