Using network analysis to personalize treatment for individuals with co-occurring restrictive eating disorders and suicidality: a proof-of-concept study.

IF 4.5 3区 医学 Q2 NUTRITION & DIETETICS
Lauren M Harris, Irina A Vanzhula, Elizabeth D Cash, Cheri A Levinson, April R Smith
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Abstract

Background: Nomothetic (i.e., on average) eating disorder interventions generally provide insufficient guidance for managing suicidality. The present proof-of-concept study demonstrates how idiographic network models can be used to inform a modular, highly personalized approach to treatment for individuals experiencing suicidality in the context of Anorexia Nervosa spectrum disorders (ANSD).

Methods: Using 21 days of ecological momentary assessment data (105 assessment points), contemporaneous and temporal idiographic symptom networks were generated for three patients with unique clinical presentations of ANSD. For each patient, we identify the most central symptoms in their network, as well as potentially important bridge symptoms linking eating pathology and suicidality. We then provide guidelines for using this information to guide the delivery of evidence-based intervention strategies.

Results: Intervention strategies may vary substantially depending upon which network statistics are used to guide treatment target selection. Bridge symptoms, or symptoms that serve as links between eating pathology and suicidality, may represent particularly promising intervention targets for individuals experiencing these conditions concurrently. Interventions which target the symptoms with the highest strength centrality may also yield symptom improvement throughout the entire network.

Conclusions: Although the viability of network-informed, personalized treatment is contingent upon continued intervention development research, this approach has the potential to improve treatment outcomes for individuals with co-occurring eating disorders and suicidality.

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使用网络分析对同时发生限制性饮食失调和自杀的个体进行个性化治疗:一项概念验证研究。
背景:普通(即平均)饮食失调干预通常不能提供足够的自杀管理指导。目前的概念验证研究表明,具体的网络模型可以用来告知模块化的,高度个性化的方法来治疗厌食症神经性谱系障碍(ANSD)患者的自杀经历。方法:利用21天的生态瞬时评估数据(105个评估点),对3例具有独特临床表现的ANSD患者进行同期和时间特异性症状网络的构建。对于每个患者,我们确定了他们网络中最核心的症状,以及连接饮食病理学和自杀倾向的潜在重要桥梁症状。然后,我们为使用这些信息来指导循证干预策略的实施提供指南。结果:干预策略可能会有很大的不同,这取决于使用哪个网络统计来指导治疗目标的选择。桥状症状,或作为饮食病理和自杀之间联系的症状,对于同时经历这些情况的个体来说可能是特别有希望的干预目标。针对具有最高强度中心性的症状的干预措施也可能在整个网络中产生症状改善。结论:尽管网络知情的个性化治疗的可行性取决于持续的干预发展研究,但这种方法有可能改善同时发生饮食失调和自杀的个体的治疗结果。
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来源期刊
Journal of Eating Disorders
Journal of Eating Disorders Neuroscience-Behavioral Neuroscience
CiteScore
5.30
自引率
17.10%
发文量
161
审稿时长
16 weeks
期刊介绍: Journal of Eating Disorders is the first open access, peer-reviewed journal publishing leading research in the science and clinical practice of eating disorders. It disseminates research that provides answers to the important issues and key challenges in the field of eating disorders and to facilitate translation of evidence into practice. The journal publishes research on all aspects of eating disorders namely their epidemiology, nature, determinants, neurobiology, prevention, treatment and outcomes. The scope includes, but is not limited to anorexia nervosa, bulimia nervosa, binge eating disorder and other eating disorders. Related areas such as important co-morbidities, obesity, body image, appetite, food and eating are also included. Articles about research methodology and assessment are welcomed where they advance the field of eating disorders.
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