Using electronic health records to identify computed tomography brain features associated with post-stroke dementia: A feasibility study.

IF 0.9 Q2 MEDICINE, GENERAL & INTERNAL

Journal of the Royal College of Physicians of Edinburgh Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI:10.1177/14782715251358924

Emily L Ball, Gillian E Mead, Terence J Quinn, Dorota Religa, Joanna M Wardlaw, Susan D Shenkin

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引用次数: 0

Abstract

Background: We explored the feasibility of linking research datasets to electronic health records to identify acute stroke computed tomography (CT) brain features associated with post-stroke dementia.

Methods: We linked data from two existing research datasets of people who had a stroke. These datasets contained expert-coded features from CT brain scans. Participants were followed up by linking to their electronic health records. Survival analyses were performed to identify prognostic factors associated with increased risk of post-stroke dementia.

Results: Twenty-one participants (11%, n = 21/185) were identified as having dementia after stroke (median follow-up: 9 years and 8 months). Presence of cerebral atrophy and moderate-to-severe white matter hyperintensities on acute stroke CT scans were associated with an increased risk of post-stroke dementia.

Conclusion: Linkage to electronic health records is a feasible method for studying dementia outcomes after stroke. This method can be applied to larger stroke populations to explore acute stroke imaging predictors in more detail.

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使用电子健康记录识别与脑卒中后痴呆相关的计算机断层扫描脑特征：可行性研究

背景：我们探索了将研究数据集与电子健康记录联系起来，以识别与脑卒中后痴呆相关的急性卒中计算机断层扫描（CT）脑特征的可行性。方法：我们将两个现有的中风患者研究数据集的数据联系起来。这些数据集包含来自CT脑部扫描的专家编码特征。通过链接参与者的电子健康记录对他们进行跟踪。进行生存分析以确定与卒中后痴呆风险增加相关的预后因素。结果：21名参与者（11%,n = 21/185）被确定为卒中后痴呆（中位随访：9年8个月）。急性卒中CT扫描中出现脑萎缩和中重度白质高信号与卒中后痴呆风险增加有关。讨论：与电子健康记录联动是研究脑卒中后痴呆结局的可行方法。这种方法可以应用于更大的中风人群，以更详细地探索急性中风成像预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Royal College of Physicians of Edinburgh MEDICINE, GENERAL & INTERNAL-

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of the Royal College of Physicians of Edinburgh (JRCPE) is the College’s quarterly, peer-reviewed journal, with an international circulation of 8,000. It has three main emphases – clinical medicine, education and medical history. The online JRCPE provides full access to the contents of the print journal and has a number of additional features including advance online publication of recently accepted papers, an online archive, online-only papers, online symposia abstracts, and a series of topic-specific supplements, primarily based on the College’s consensus conferences.