Opportunities for Pharmacogenomics in Pediatrics: Prescribing Trends of Psychiatric Medications With Pharmacogenomic Implications at a Multistate Pediatric Health System.

Q2 Medicine
Megan L Miller, Nathan D Seligson, Benjamin Q Duong, Josephine Elia, Shirin Hasan, Thomas Lacy, Kathryn V Blake, Kelsey J Cook
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引用次数: 0

Abstract

The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published guidelines providing pharmacogenomic (PGx) recommendations for more than 100 drugs; however, limited data exist describing prescribing patterns of these medications in pediatric populations. With increasing evidence describing the benefits of PGx testing to tailor drug therapy in psychiatric conditions, along with a worsening mental health crisis in pediatrics, it is vital to assess the prevalence of medication prescribing and potential impact of implementing PGx testing in this population. Here we describe prescribing patterns of psychiatric drugs classified as CPIC level A/B from January 1, 2010, through December 31, 2020, across Nemours Children's Health, a multistate pediatric health care system. We identified 21,442 unique patients who received at least 1 indicated medication during this period. The most frequently prescribed medications were amitriptyline and sertraline. Overall prescribing was highest in the departments of neurology, primary care, and psychiatry with selective serotonin reuptake inhibitors (SSRIs) being the most frequently prescribed medication class. These findings indicate ample opportunity for PGx implementation targeting these medications. Identification of high-prescribing departments and specific medications prescribed will help focus PGx implementation and education efforts.

儿科药物基因组学的机会:在多州儿科卫生系统中药物基因组学影响的精神药物处方趋势。
临床药物遗传学实施联盟(CPIC)已经发布了指南,为100多种药物提供药物基因组学(PGx)建议;然而,在儿科人群中描述这些药物的处方模式的数据有限。随着越来越多的证据表明,PGx检测对精神病患者量身定制药物治疗的好处,以及儿科心理健康危机的恶化,评估药物处方的流行程度和在这一人群中实施PGx检测的潜在影响至关重要。本文描述了2010年1月1日至2020年12月31日期间,内穆尔儿童健康中心(Nemours Children’s Health,一个多州儿科医疗保健系统)精神科药物被归类为CPIC A/B级的处方模式。我们确定了21442名在此期间接受至少一种指示性药物治疗的独特患者。最常用的处方药是阿米替林和舍曲林。总的来说,神经科、初级保健科和精神科的处方量最高,其中选择性血清素再摄取抑制剂(SSRIs)是最常用的处方药。这些发现表明针对这些药物的PGx实施有充足的机会。确定高处方部门和特定药物处方将有助于重点PGx的实施和教育工作。
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来源期刊
Journal of Pediatric Pharmacology and Therapeutics
Journal of Pediatric Pharmacology and Therapeutics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
2.40
自引率
0.00%
发文量
90
期刊介绍: The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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