[Analysis of the content of some chemical trace elements in intact tooth enamel of individuals with different frequency of polymorphisms of the kallikrein-4 gene].

Abstract

The aim the study. Assessment of the content of various trace elements in the intact tooth enamel of individuals genotyped by polymorphism G/G, G/A, A/A of the kallikrein-4 gene at mutational points G2664153A and G2142A.

Material and methods: Laboratory examination of 160 enamel samples of intact premolars of the upper jaws removed according to orthodontic indications in individuals with different genotypes of G/G, G/A and A/A of the kallikrein-4 gene at mutation points G2664153A and G2142A was carried out using X-ray spectral fluorescence analysis.

Results: In the intact tooth enamel of individuals with an increase in the frequency of polymorphism G/G of the kallikrein-4 gene, there is a significant increase in the concentration of fluorine, iron, strontium, silicon. In the intact tooth enamel of individuals with an increase in the frequency of polymorphism A/A of the kallikrein-4 gene, there is a significant increase in the concentration of magnesium, zinc, aluminum, sulfur, and chlorine. Concentrations of the main trace elements involved in remineralization (calcium and phosphorus) have no statistical significance in intact tooth enamel of individuals with both G/G polymorphism and A/A polymorphism of the kallikrein-4 gene at mutation points G2664153A and G2142A.

Conclusion: Mutation of the kallikrein-4 gene in positions G2664153A and G2142A is accompanied by a change in the quantitative content of a number of trace elements in the tooth enamel of individuals with polymorphisms G/G and A/A, without affecting the concentration of calcium and phosphorus.