Karolaine Santos Teixeira, Hillquias Monteiro Moreira, Tárcio Peixoto Roca, Edilene Pereira Pimentel, Jackson Alves da Silva Queiroz, Jessiane Rodrigues Ribeiro, Ana Maisa Passos-Silva, Adrhyan Araújo, Kátia Ingred da Silva Maia, Felipe Gomes Naveca, Ighor Arantes, Gonzalo Bello, Jansen Fernandes de Medeiros, Marco Aurelio Krieger, Juan Miguel Villalobos Salcedo, Rita de Cássia Pontello Rampazzo, Deusilene Vieira
{"title":"Reemergence of Oropouche in the Brazilian Amazon: A phylodynamic and phylogenetic analysis.","authors":"Karolaine Santos Teixeira, Hillquias Monteiro Moreira, Tárcio Peixoto Roca, Edilene Pereira Pimentel, Jackson Alves da Silva Queiroz, Jessiane Rodrigues Ribeiro, Ana Maisa Passos-Silva, Adrhyan Araújo, Kátia Ingred da Silva Maia, Felipe Gomes Naveca, Ighor Arantes, Gonzalo Bello, Jansen Fernandes de Medeiros, Marco Aurelio Krieger, Juan Miguel Villalobos Salcedo, Rita de Cássia Pontello Rampazzo, Deusilene Vieira","doi":"10.1016/j.tmaid.2025.102877","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The distribution of arboviruses in endemic regions is experiencing a significant shift, along with the re-emergence of Oropouche virus (OROV) as a significant pathogen, characterized by dynamic vector-borne transmission. Despite growing public health relevance, OROV remains insufficiently characterized, with limited comprehensive genomic and epidemiological data. This knowledge gap affects the accuracy of diagnostic approaches and limits the effectiveness of surveillance and control strategies. This study aimed to characterize the re-emergence of OROV in endemic regions, elucidate its epidemiological distribution, and clarify the epidemiological distribution of OROV and assess its impact on diagnostic strategies and surveillance for acute febrile illness.</p><p><strong>Methods: </strong>Between January and July 2024, a total of 869 individuals with malaria-negative acute febrile illness were screened for dengue, Zika, and chikungunya viruses. Duplex RT-qPCR assays were subsequently employed to detect Mayaro and Oropouche viruses. Spatiotemporal and geospatial analyses were conducted to assess the distribution of OROV in relation to environmental factors.</p><p><strong>Findings: </strong>Among the participants, 35 % tested positive for OROV, with cases predominantly concentrated in forest and riverine areas. Considering that the significant increase in the number of cases occurred in a short space of time, the results highlight the urgent need to strengthen genomic and epidemiological surveillance to tackle emerging arboviral threats.</p>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":" ","pages":"102877"},"PeriodicalIF":4.7000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Travel Medicine and Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tmaid.2025.102877","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The distribution of arboviruses in endemic regions is experiencing a significant shift, along with the re-emergence of Oropouche virus (OROV) as a significant pathogen, characterized by dynamic vector-borne transmission. Despite growing public health relevance, OROV remains insufficiently characterized, with limited comprehensive genomic and epidemiological data. This knowledge gap affects the accuracy of diagnostic approaches and limits the effectiveness of surveillance and control strategies. This study aimed to characterize the re-emergence of OROV in endemic regions, elucidate its epidemiological distribution, and clarify the epidemiological distribution of OROV and assess its impact on diagnostic strategies and surveillance for acute febrile illness.
Methods: Between January and July 2024, a total of 869 individuals with malaria-negative acute febrile illness were screened for dengue, Zika, and chikungunya viruses. Duplex RT-qPCR assays were subsequently employed to detect Mayaro and Oropouche viruses. Spatiotemporal and geospatial analyses were conducted to assess the distribution of OROV in relation to environmental factors.
Findings: Among the participants, 35 % tested positive for OROV, with cases predominantly concentrated in forest and riverine areas. Considering that the significant increase in the number of cases occurred in a short space of time, the results highlight the urgent need to strengthen genomic and epidemiological surveillance to tackle emerging arboviral threats.
期刊介绍：
Travel Medicine and Infectious Disease
Publication Scope:
Publishes original papers, reviews, and consensus papers
Primary theme: infectious disease in the context of travel medicine
Focus Areas:
Epidemiology and surveillance of travel-related illness
Prevention and treatment of travel-associated infections
Malaria prevention and treatment
Travellers' diarrhoea
Infections associated with mass gatherings
Migration-related infections
Vaccines and vaccine-preventable disease
Global policy/regulations for disease prevention and control
Practical clinical issues for travel and tropical medicine practitioners
Coverage:
Addresses areas of controversy and debate in travel medicine
Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease
Publication Features:
Offers a fast peer-review process
Provides early online publication of accepted manuscripts
Aims to publish cutting-edge papers
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
