Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-07-24 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1227

Nedim Uzun, Ozgecan Gundogar, Naile Misirlioglu, Emine Yildirim, Neslin Sahin, Seyma Dumur, Hafize Uzun

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引用次数: 0

Abstract

Objectives: Accurate diagnosis of acute cholecystitis (AC) is critical because early laparoscopic cholecystectomy significantly reduces complications and mortality. This study evaluates the predictive value of inflammatory indices and hematological markers in diagnosing AC.

Methods: A retrospective review was performed on early laparoscopic cholecystectomy cases at the Gaziosmanpaşa Training and Research Hospital in Istanbul between August 2013 and August 2023. Patient demographics, preoperative laboratory values, inflammatory indices - including neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) - were evaluated, along with hospital length of stay and histopathological outcomes.

Results: Among 249 patients, 34 (13.6%) were diagnosed with AC, comprising 76 males (30.5%) and 173 females (69.5%), with a mean age of 48.9 ± 14.6 years. The median hospital length of stay was 3 days (range: 1-21). Significant elevations in both the SIRI and neutrophil count were observed in AC cases compared to controls (P < 0.001). ROC (receiver operating characteristic) curve analysis demonstrated comparable diagnostic performance for the SIRI (AUC = 0.746; 95% CI: 0.658-0.835; optimal cutoff: 1.98) and neutrophil count (AUC = 0.746; 95% CI: 0.658-0.835; optimal cutoff: 7.1 × 10³/μL) in predicting AC.

Conclusions: The SIRI and neutrophil count are reliable markers that can improve the diagnostic accuracy and guide early management of AC.

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血液学参数在急性胆囊炎早期诊断中的价值。

目的：准确诊断急性胆囊炎（AC）是至关重要的，因为早期腹腔镜胆囊切除术可显著减少并发症和死亡率。方法：回顾性分析2013年8月至2023年8月伊斯坦布尔gaziosmanpa培训与研究医院早期腹腔镜胆囊切除术病例。评估患者人口统计学、术前实验室值、炎症指数——包括中性粒细胞与淋巴细胞比率（NLR）、全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）和全身炎症综合指数（AISI），以及住院时间和组织病理学结果。结果249例患者中34例（13.6%）确诊为AC，其中男性76例（30.5%），女性173例（69.5%），平均年龄48.9±14.6岁。住院时间中位数为3天（范围：1-21天）。与对照组相比，AC患者的SIRI和中性粒细胞计数均显著升高（P < 0.001）。ROC（受试者工作特征）曲线分析显示，SIRI的诊断性能相当(AUC = 0.746；95% ci: 0.658-0.835；最佳临界值：1.98)和中性粒细胞计数(AUC = 0.746；95% ci: 0.658-0.835；结论：SIRI和中性粒细胞计数是预测AC的可靠指标，可提高AC的诊断准确性，指导AC的早期治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.