Association of AOC3 Expression in Visceral Adipose Tissue and Circulating Soluble Vascular Adhesion Protein-1 with Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Japanese Patients with Severe Obesity.
Osamu Horikawa, Maika Ikeda, Miwako Togawa, Yuta Koshikawa, Yasuhiro Watanabe, Yuka Takahashi, Taiki Nabekura, Daiji Nagayama, Kohji Shirai, Atsuhito Saiki
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引用次数: 0
Abstract
Introduction: Soluble vascular adhesion protein-1 (sVAP-1), which is identical to semicarbazide-sensitive amine oxidase (SSAO), contributes to oxidative stress and vascular dysfunction. The AOC3 gene that encodes VAP-1 is mainly expressed in vascular endothelial and smooth muscle cells, but AOC3 expression in adipose tissue and vascular implications remain unclear. The aim of this study was to investigate the association of adipose AOC3 expression and circulating sVAP-1/SSAO with arterial stiffness in patients with severe obesity.
Methods: We studied 49 Japanese patients who underwent laparoscopic sleeve gastrectomy. AOC3 expression was measured in visceral and subcutaneous adipose tissues obtained during surgery. Circulating sVAP-1 concentration, SSAO activity, oxidative stress markers, and cardio-ankle vascular index (CAVI) were assessed. Correlation and multiple regression analyses were performed.
Results: Serum sVAP-1 concentration correlated strongly with SSAO activity (rs = 0.683, p < 0.001) and was directly associated with CAVI. Visceral AOC3 Gene Index (AOC3 expression × visceral fat area) was independently associated with serum sVAP-1 concentration, whereas subcutaneous AOC3 expression was not. Subcutaneous fat area showed an inverse association with SSAO activity. In stratified analysis, patients with visceral-dominant obesity had higher CAVI, serum sVAP-1 concentration, and SSAO activity than those with subcutaneous-dominant obesity.
Conclusions: Visceral fat-derived AOC3 expression correlates with serum sVAP-1 concentration that appears to contribute to arterial stiffness in obesity. In contrast, subcutaneous fat may be associated with reduced SSAO activity. These findings highlight the fat depot-specific role of adipose tissue in vascular health and implicate VAP-1 as a potential mediator of obesity-related atherosclerosis.
期刊介绍：
''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.
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