Effects of coronavirus disease 2019 in patients with optic neuritis: a single-centre retrospective cohort study.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-07-29 DOI:10.1007/s10072-025-08365-7

Rong Yan, Yanjun Guo, Chao Meng, Xiuyun Kong, Jiawei Wang

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引用次数: 0

Abstract

Background: The relationship between coronavirus disease 2019 (COVID-19) and optic neuritis (ON) remains unclear, with limited evidence on its clinical features and outcomes. This study aimed to investigate the impact of COVID-19 on ON subtypes and prognosis.

Methods: We conducted a single-centre retrospective cohort study, comparing acute ON patients with and without recent COVID-19 infection during the omicron wave (December 2022 to January 2023). A historical control group from the pre-COVID-19 era was included for comparison.

Results: A total of 55 ON patients were included, of whom 12 had recent COVID-19 infection. COVID-19-associated ON showed a higher incidence of acute disseminated encephalomyelitis-associated ON (ADEM-ON, 25% vs. 0%) and a lower rate of aquaporin-4 antibody-associated ON (AQP4-ON, 0% vs. 31.4%). These patients presented more frequently with eye pain (75%) and respiratory symptoms (60%). At onset, 66.7% experienced severe visual loss (mean logMAR 1.10 ± 0.71), but most (83.3%) achieved good visual recovery (mean logMAR 0.08 ± 0.44) after immunotherapy. Only one relapse was observed during follow-up.

Conclusions: COVID-19 may trigger distinct autoimmune processes in ON, particularly increasing ADEM-ON prevalence. Despite initial severe vision loss, outcomes are generally favourable with timely treatment. These findings expand understanding of neuro-ophthalmic complications related to COVID-19.

查看原文本刊更多论文

2019冠状病毒病对视神经炎患者的影响：一项单中心回顾性队列研究

背景：2019冠状病毒病（COVID-19）与视神经炎（ON）之间的关系尚不清楚，其临床特征和结局的证据有限。本研究旨在探讨COVID-19对on亚型和预后的影响。方法：我们进行了一项单中心回顾性队列研究，比较了在欧微米波期间（2022年12月至2023年1月）有和没有近期COVID-19感染的急性ON患者。纳入新冠肺炎前的历史对照组进行比较。结果：共纳入55例ON患者，其中12例近期感染。covid -19相关ON的急性播散性脑脊髓炎相关ON的发生率较高（ADEM-ON， 25%比0%），而水通道蛋白-4抗体相关ON的发生率较低（AQP4-ON， 0%比31.4%）。这些患者更常出现眼痛（75%）和呼吸道症状（60%）。发病时，66.7%的患者出现严重视力丧失（平均logMAR为1.10±0.71），但大多数患者（83.3%）在免疫治疗后视力恢复良好（平均logMAR为0.08±0.44）。随访期间仅观察到1例复发。结论：COVID-19可能在ON中引发独特的自身免疫过程，特别是增加ADEM-ON的患病率。尽管最初严重的视力丧失，但及时治疗的结果通常是有利的。这些发现扩大了对与COVID-19相关的神经眼科并发症的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.