Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii.

IF 12.7 1区生物学 Q1 MICROBIOLOGY

Microbiome Pub Date : 2025-07-28 DOI:10.1186/s40168-025-02168-w

Koji Hosomi, Satoko Maruyama, Tsubasa Matsuoka, Mari Furuta, Yoko Tojima, Keita Uchiyama, Makiko Morita, Hitoshi Kawashima, Toshiki Kobayashi, Jun Kunisawa

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引用次数: 0

Abstract

Background: The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health.

Results: We identified a unique interaction between the pathobiont Fusobacterium varium and the symbiont Faecalibacterium prausnitzii, both members of the gut microbial community; their interaction is driven by metabolites and direct cell-to-cell contact. Growth of F. varium was inhibited in the presence of F. prausnitzii because of a decrease in pH and an increase in β-hydroxybutyric acid. Conversely, the growth of F. prausnitzii was promoted in the presence of F. varium, likely via direct contact.

Conclusions: These findings highlight the importance of metabolite-driven interactions and direct contact in shaping gut microbial communities and emphasize the potential of interactions between F. prausnitzii and F. varium in influencing gut health. Video Abstract.

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不同梭杆菌和prausnitzii粪杆菌之间代谢物介导的相互作用和直接接触。

背景：人类肠道中蕴藏着多种多样的微生物群，它们对维持健康至关重要，但也会导致几种疾病。了解微生物群落是如何聚集和维持的对于促进肠道健康至关重要。结果：我们发现了一种独特的相互作用之间的致病菌梭杆菌和共生体prausnitzii Faecalibacterium，都是肠道微生物群落的成员；它们的相互作用是由代谢物和直接的细胞间接触驱动的。在prausnitzii存在的情况下，由于pH的降低和β-羟基丁酸的增加，抑制了F. varum的生长。相反，在有不同种类的F. varum存在的情况下，可能通过直接接触促进了prausnitzii的生长。结论：这些发现强调了代谢物驱动的相互作用和直接接触在塑造肠道微生物群落中的重要性，并强调了F. prausnitzii和F. varum之间相互作用在影响肠道健康方面的潜力。视频摘要。

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来源期刊

Microbiome MICROBIOLOGY-

CiteScore

21.90

自引率

2.60%

发文量

198

审稿时长

4 weeks

期刊介绍： Microbiome is a journal that focuses on studies of microbiomes in humans, animals, plants, and the environment. It covers both natural and manipulated microbiomes, such as those in agriculture. The journal is interested in research that uses meta-omics approaches or novel bioinformatics tools and emphasizes the community/host interaction and structure-function relationship within the microbiome. Studies that go beyond descriptive omics surveys and include experimental or theoretical approaches will be considered for publication. The journal also encourages research that establishes cause and effect relationships and supports proposed microbiome functions. However, studies of individual microbial isolates/species without exploring their impact on the host or the complex microbiome structures and functions will not be considered for publication. Microbiome is indexed in BIOSIS, Current Contents, DOAJ, Embase, MEDLINE, PubMed, PubMed Central, and Science Citations Index Expanded.