The underlying mechanism of physical exercise on neurodegenerative diseases: the mediating role of psychological stress and resilience: a systematic review.
Qingxia Jiang, Yan Liu, Yong Wei, Garry Kuan, Lei Ma, Huarong Wang, Yaxian Wang, Hu Lou
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引用次数: 0
Abstract
Theories and experiments have shown that physical exercise can improve mental resilience and resist the negative effects of psychological stress. Neurodegenerative diseases are a collection of diseases in which progressive changes in the structure and function of neurons result in progressive disorders of cognitive and motor function, greatly reducing the quality of life of the patient. The latest research suggests that psychological factors such as psychological stress and resilience also have an impact on the onset, symptoms, and course of Neurodegenerative diseases. However, the specific mechanisms in the above pathways are unclear, so this study introduced psychological factors such as psychological stress and resilience and explore the mechanism of physical exercise in improving NDDs by influencing psychological factors such as psychological stress and resilience. This review examined four electronic databases (PubMed, Web of Science, Cochrane Library, and CNKI) up to May 2024, selecting a total of 95 articles. A logical analysis approach was employed to evaluate the literature. The findings revealed that: (1) Exercise can enhance resilience by reducing negative emotions or fulfilling individual needs, thereby diminishing the harmful effects of stress, a key risk factor for NDDs. (2) Exercise alleviates NDDs through neurobiological pathways such as improving immune function, regulating endocrine and neurotransmitter levels, and modifying neuronal structure. (3) Long-term, regular high-intensity exercise effectively enhances resilience and helps prevent and treat NDDs. Exercise has a positive impact on the prevention and treatment of NDDs. Clarifying the mechanisms by which exercise improves NDDs is crucial for providing new theoretical insights into the diagnosis, prevention, and treatment of psychologically induced NDDs, as well as offering practical guidance and feasible strategies for using exercise to prevent and mitigate NDDs.
理论和实验表明，体育锻炼可以提高心理弹性，抵御心理压力的负面影响。神经退行性疾病是指神经元结构和功能的进行性改变导致认知和运动功能进行性障碍，大大降低患者生活质量的一系列疾病。最新的研究表明，心理因素，如心理压力和弹性也对神经退行性疾病的发病、症状和病程有影响。但上述途径的具体机制尚不清楚，因此本研究引入心理应激、心理弹性等心理因素，探讨体育锻炼通过影响心理应激、心理弹性等心理因素改善ndd的机制。本综述对截至2024年5月的四个电子数据库（PubMed、Web of Science、Cochrane Library和CNKI）进行了检索，共选择了95篇文章。采用逻辑分析方法对文献进行评价。研究结果表明：(1)运动可以通过减少负面情绪或满足个体需求来增强韧性，从而减少压力的有害影响，而压力是ndd的关键危险因素。(2)运动可通过改善免疫功能、调节内分泌和神经递质水平、改变神经元结构等神经生物学途径缓解ndd。(3)长期规律的高强度运动能有效增强韧性，有助于预防和治疗ndd。运动对ndd的预防和治疗有积极的影响。阐明运动改善ndd的机制对于为心理诱导ndd的诊断、预防和治疗提供新的理论见解，以及为利用运动预防和减轻ndd提供实践指导和可行策略至关重要。
期刊介绍：
Frontiers in Psychology is the largest journal in its field, publishing rigorously peer-reviewed research across the psychological sciences, from clinical research to cognitive science, from perception to consciousness, from imaging studies to human factors, and from animal cognition to social psychology. Field Chief Editor Axel Cleeremans at the Free University of Brussels is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal publishes the best research across the entire field of psychology. Today, psychological science is becoming increasingly important at all levels of society, from the treatment of clinical disorders to our basic understanding of how the mind works. It is highly interdisciplinary, borrowing questions from philosophy, methods from neuroscience and insights from clinical practice - all in the goal of furthering our grasp of human nature and society, as well as our ability to develop new intervention methods.
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