{"title":"Bioactive Properties of <i>Persea americana</i> Peel Extract and Their Role in Hypercholesterolemia Management and Cardiovascular Health.","authors":"Laura M Teixeira, Catarina P Reis, Rita Pacheco","doi":"10.3390/foods14142482","DOIUrl":null,"url":null,"abstract":"<p><p>Cardiovascular diseases remain the leading cause of death worldwide, with hypercholesterolemia being a major contributing risk factor. Although cholesterol-lowering drugs are widely available, concerns about several adverse side effects have increased the demand for natural alternatives, with the most common approaches involving the incorporation of foods rich in bioactive compounds into the diet. To explore this growing interest in food-based strategies for cardiovascular health, this study formulated and evaluated an aqueous peel extract of <i>Persea americana</i> to assess its potential role as a complementary approach to managing hypercholesterolemia. The extract was characterized, revealing the presence of various bioactive compounds, including pyridoxine-O-Hex, which was identified for the first time in a <i>P. americana</i> extract component. The safety profile of the extract was confirmed through in vivo assessment. Furthermore, the extract demonstrated protective effects against oxidative stress in HepG2 cells. Additionally, permeability studies using Caco-2 cells, as a model of the gastrointestinal barrier, indicated that the extract effectively reduced cholesterol's permeation. In summary, these findings suggest that <i>P. americana</i> peel extract may serve as a promising natural product for functional foods for cardiovascular health and hypercholesterolemia management.</p>","PeriodicalId":12386,"journal":{"name":"Foods","volume":"14 14","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294314/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Foods","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3390/foods14142482","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cardiovascular diseases remain the leading cause of death worldwide, with hypercholesterolemia being a major contributing risk factor. Although cholesterol-lowering drugs are widely available, concerns about several adverse side effects have increased the demand for natural alternatives, with the most common approaches involving the incorporation of foods rich in bioactive compounds into the diet. To explore this growing interest in food-based strategies for cardiovascular health, this study formulated and evaluated an aqueous peel extract of Persea americana to assess its potential role as a complementary approach to managing hypercholesterolemia. The extract was characterized, revealing the presence of various bioactive compounds, including pyridoxine-O-Hex, which was identified for the first time in a P. americana extract component. The safety profile of the extract was confirmed through in vivo assessment. Furthermore, the extract demonstrated protective effects against oxidative stress in HepG2 cells. Additionally, permeability studies using Caco-2 cells, as a model of the gastrointestinal barrier, indicated that the extract effectively reduced cholesterol's permeation. In summary, these findings suggest that P. americana peel extract may serve as a promising natural product for functional foods for cardiovascular health and hypercholesterolemia management.
心血管疾病仍然是世界范围内死亡的主要原因,高胆固醇血症是一个主要的危险因素。虽然降胆固醇药物广泛可用,但对一些副作用的担忧增加了对天然替代品的需求,最常见的方法是在饮食中加入富含生物活性化合物的食物。为了探索人们对以食物为基础的心血管健康策略日益增长的兴趣,本研究制定并评估了美洲波斯水果皮提取物,以评估其作为治疗高胆固醇血症的补充方法的潜在作用。对该提取物进行了表征,发现其存在多种生物活性化合物,包括首次在美洲紫檀提取物成分中鉴定出的吡哆醇- o - hex。该提取物的安全性通过体内评估得到证实。此外,该提取物对HepG2细胞的氧化应激具有保护作用。此外,以Caco-2细胞作为胃肠道屏障模型的通透性研究表明,提取物有效降低了胆固醇的通透性。综上所述,这些发现表明美洲胡杨树果皮提取物可能是一种很有前途的功能性食品,用于心血管健康和高胆固醇血症的管理。
期刊介绍:
Foods (ISSN 2304-8158) is an international, peer-reviewed scientific open access journal which provides an advanced forum for studies related to all aspects of food research. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists, researchers, and other food professionals to publish their experimental and theoretical results in as much detail as possible or share their knowledge with as much readers unlimitedly as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal:
manuscripts regarding research proposals and research ideas will be particularly welcomed
electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material
we also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds