Effects of glucose and fructose supplementation on serum sex hormone-binding globulin and testosterone levels: Post-hoc analysis of a double-blind randomized controlled trial

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-07-26 DOI:10.1016/j.clnesp.2025.07.1123

Huadong Chen , Pomme I.H.G. Simons , Nynke Simons , Marjo P.H. van de Waarenburg , J.A.P. Bons , E.M.C. van der Ploeg (Liesbeth) , Edith J.M. Feskens , Casper G. Schalkwijk , Martijn C.G.J. Brouwers

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引用次数: 0

Abstract

Background&aims

Previous laboratory studies have shown that simple sugars impair the hepatic synthesis of sex hormone-binding globulin (SHBG). This study aimed to assess whether fructose or glucose differentially affect serum SHBG and (free) testosterone levels in humans.

Methods

This is a secondary analysis of the FRUITLESS trial, a double-blind, randomized controlled study, including 36 participants (BMI ≥28 kg/m², fatty liver index ≥60). Participants followed a 6-week fructose-restricted diet and were supplemented with either fructose or glucose, matched to the amount of natural fructose that was removed from the diet. Differences between groups were analyzed using analysis of covariance (ANCOVA) with adjustment for sex.

Results

No significant differences were observed between fructose and glucose supplementation groups in serum SHBG (regression coefficient: +7.7 nmol/L, 95 % CI: −7.0; 22.4), total testosterone (+2.9 nmol/L, 95 % CI: −0.4; 6.2), or free testosterone (−1.9 pmol/L, 95 % CI: −93.0; 89.1). Sex-stratified analyses revealed similar results.

Conclusion

Fructose and glucose supplementation do not differentially impact serum SHBG or (free) testosterone levels at a clinically meaningful level.

The study was registered at ClinicalTrials.gov (NCT03067428) and were approved by the Medical Ethics Committee of Maastricht University Medical Center (NL58360.068.16).

查看原文本刊更多论文

葡萄糖和果糖补充对血清性激素结合球蛋白和睾酮水平的影响：一项双盲随机对照试验的事后分析

背景与目的：先前的实验室研究表明，单糖损害性激素结合球蛋白（SHBG）的肝脏合成。本研究旨在评估果糖或葡萄糖对人类血清SHBG和（游离）睾酮水平的影响是否存在差异。方法：这是对FRUITLESS试验的二次分析，这是一项双盲，随机对照研究，包括36名参与者（BMI≥28 kg/m2，脂肪肝指数≥60）。参与者遵循为期6周的果糖限制饮食，并补充果糖或葡萄糖，与从饮食中去除的天然果糖的量相匹配。采用协方差分析（ANCOVA）分析组间差异，并对性别进行校正。结果：果糖补充组和葡萄糖补充组血清SHBG（回归系数：+7.7 nmol/L, 95% CI: -7.0;22.4）、总睾酮(+2.9 nmol/L, 95% CI: -0.4；6.2)或游离睾酮(-1.9 pmol/L, 95% CI: -93.0；89.1)。性别分层分析显示了类似的结果。结论：在临床意义水平上，果糖和葡萄糖补充对血清SHBG或（游离）睾酮水平没有差异。该研究已在ClinicalTrials.gov注册（NCT03067428），并获得马斯特里赫特大学医学中心医学伦理委员会（NL58360.068.16）的批准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.