The Immune Regulatory Functions of CD226 and Its Implications in Immune-Mediated Diseases.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-07-14 DOI:10.3390/biom15071007

Keyan Liu, Yuanzhen Liu, Huabao Xiong, Zhaochen Ning

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引用次数: 0

Abstract

CD226, a member of the immunoglobulin superfamily, serves as a critical regulator in various immunological processes. CD226 is expressed across immune and non-immune cells, with predominant expression being observed in natural killer (NK) cells and T cells. By engaging ligands CD155 and CD112, it orchestrates diverse signaling pathways that modulate T cell differentiation and effector functions while enhancing NK cell activation and cytotoxicity. Genetic polymorphisms and the dysregulated expression of CD226 are closely associated with susceptibility to autoimmune diseases, infectious diseases, allergic diseases, and cancer progression. Growing evidence highlight CD226's emerging promise as a therapeutic target for immune-mediated diseases. The present work aims to review the current understanding of CD226's role in immune responses and to comprehensively outline its multifaceted involvement in different immunological diseases, providing insights for future research to advance our mechanistic understanding of its roles in disease pathogenesis.

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CD226的免疫调节功能及其在免疫介导疾病中的意义

CD226是免疫球蛋白超家族的一员，在各种免疫过程中起着重要的调节作用。CD226在免疫和非免疫细胞中均有表达，主要表达于自然杀伤细胞（NK）和T细胞。通过结合配体CD155和CD112，它协调多种信号通路，调节T细胞分化和效应功能，同时增强NK细胞活化和细胞毒性。遗传多态性和CD226表达失调与自身免疫性疾病、感染性疾病、过敏性疾病和癌症进展的易感性密切相关。越来越多的证据强调CD226作为免疫介导性疾病的治疗靶点的新兴前景。本研究旨在回顾目前对CD226在免疫应答中的作用的认识，并全面概述其在不同免疫疾病中的多方面参与，为未来的研究提供见解，以推进我们对其在疾病发病机制中的作用的机制理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.