Serum neuropilin-1 level may predict airway remodeling based on age and smoking status in asthma.

IF 2.1 Q3 ALLERGY

Asia Pacific Allergy Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI:10.5415/apallergy.0000000000000192

Ji-Yoon Oh, Chae Eun Lee, Seo Young Kim, Hyunkyoung Kim, Yu Ri Kang, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Tae-Bum Kim

{"title":"Serum neuropilin-1 level may predict airway remodeling based on age and smoking status in asthma.","authors":"Ji-Yoon Oh, Chae Eun Lee, Seo Young Kim, Hyunkyoung Kim, Yu Ri Kang, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Tae-Bum Kim","doi":"10.5415/apallergy.0000000000000192","DOIUrl":null,"url":null,"abstract":"Background: Airway remodeling in asthma is induced by the production of vascular endothelial growth factor, and this process is mediated by neuropilin-1 (NRP-1).Objective: To investigate the association between the serum level of NRP-1 and clinical characteristics in asthma.Methods: We measured the serum level of NRP-1 and performed subgroup analysis of NRP-1 according to the clinical characteristics of 421 asthma patients registered in the Cohort for Reality and Evolution of Adult Asthma in Korea.Results: The serum level of NRP-1 was significantly higher in the group under 65 years of age than in the group over 65 years of age (1628.36 ± 589.51 vs 1416.75 ± 671.42; P < 0.001). Current smokers and ex-smokers had a significantly higher serum NRP-1 level compared with that of never smokers (1647.16 ± 572.34 vs 1528.5 ± 579.37; P = 0.041). Medium- and high-inhaled corticosteroid users had a higher serum NRP-1 level compared with that of low-inhaled corticosteroid users (1589.87 ± 591.7 vs 1436.12 ± 419.21; P = 0.049). The serum NRP-1 level was significantly higher in the group with a forced vital capacity (FVC) of 70% or higher than in the group with an FVC of 70% or lower. In univariate analysis, age was a factor influencing serum NRP-1 with a negative correlation (coefficient=-260.90; P < 0.001). Ex-smokers and current smokers were factors influencing serum NRP-1 with a positive correlation (coefficient = 118.66; P = 0.0412). An FVC of 70% or higher was a factor affecting serum NRP-1 with a positive correlation (coefficient = 173.86; P = 0.0224). Multivariable analysis revealed that age (coefficient = -233.53; P < 0.001) and smoking history (coefficient = -122.4; P = 0.0358) were significant variables affecting serum NRP-1.Conclusion: Serum NRP-1 level was high in asthma patients with a younger age and smoking history, suggesting its potential as a clinical marker for predicting early-stage airway remodeling based on the age and smoking status.","PeriodicalId":8488,"journal":{"name":"Asia Pacific Allergy","volume":"15 2","pages":"63-66"},"PeriodicalIF":2.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289087/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Pacific Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5415/apallergy.0000000000000192","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Airway remodeling in asthma is induced by the production of vascular endothelial growth factor, and this process is mediated by neuropilin-1 (NRP-1).

Objective: To investigate the association between the serum level of NRP-1 and clinical characteristics in asthma.

Methods: We measured the serum level of NRP-1 and performed subgroup analysis of NRP-1 according to the clinical characteristics of 421 asthma patients registered in the Cohort for Reality and Evolution of Adult Asthma in Korea.

Results: The serum level of NRP-1 was significantly higher in the group under 65 years of age than in the group over 65 years of age (1628.36 ± 589.51 vs 1416.75 ± 671.42; P < 0.001). Current smokers and ex-smokers had a significantly higher serum NRP-1 level compared with that of never smokers (1647.16 ± 572.34 vs 1528.5 ± 579.37; P = 0.041). Medium- and high-inhaled corticosteroid users had a higher serum NRP-1 level compared with that of low-inhaled corticosteroid users (1589.87 ± 591.7 vs 1436.12 ± 419.21; P = 0.049). The serum NRP-1 level was significantly higher in the group with a forced vital capacity (FVC) of 70% or higher than in the group with an FVC of 70% or lower. In univariate analysis, age was a factor influencing serum NRP-1 with a negative correlation (coefficient=-260.90; P < 0.001). Ex-smokers and current smokers were factors influencing serum NRP-1 with a positive correlation (coefficient = 118.66; P = 0.0412). An FVC of 70% or higher was a factor affecting serum NRP-1 with a positive correlation (coefficient = 173.86; P = 0.0224). Multivariable analysis revealed that age (coefficient = -233.53; P < 0.001) and smoking history (coefficient = -122.4; P = 0.0358) were significant variables affecting serum NRP-1.

Conclusion: Serum NRP-1 level was high in asthma patients with a younger age and smoking history, suggesting its potential as a clinical marker for predicting early-stage airway remodeling based on the age and smoking status.

查看原文本刊更多论文

血清神经匹林-1水平可预测哮喘患者基于年龄和吸烟状况的气道重塑。

背景：哮喘气道重构是由血管内皮生长因子的产生诱导的，这一过程是由神经肽-1 （neuropilin-1, NRP-1）介导的。目的：探讨哮喘患者血清NRP-1水平与临床特征的关系。方法：根据韩国成人哮喘现实与演变队列登记的421例哮喘患者的临床特征，测定血清NRP-1水平，并进行NRP-1亚组分析。结果：65岁以下患者血清NRP-1水平明显高于65岁以上患者（1628.36±589.51 vs 1416.75±671.42）；P < 0.001)。当前吸烟者和已戒烟者血清NRP-1水平明显高于未吸烟者（1647.16±572.34 vs 1528.5±579.37）；P = 0.041)。中、高吸入性皮质类固醇使用者血清NRP-1水平高于低吸入性皮质类固醇使用者(1589.87±591.7 vs 1436.12±419.21；P = 0.049)。肺活量(FVC)≥70%组血清NRP-1水平显著高于FVC≤70%组。单因素分析中，年龄是影响血清NRP-1的因素，且呈负相关(系数=-260.90；P < 0.001)。戒烟者和吸烟者是影响血清NRP-1的因素，两者呈正相关(系数= 118.66；P = 0.0412)。FVC≥70%与血清NRP-1呈正相关(系数= 173.86；P = 0.0224)。多变量分析显示，年龄(系数= -233.53；P < 0.001)和吸烟史(系数= -122.4；P = 0.0358)是影响血清NRP-1的显著变量。结论：年龄小、有吸烟史的哮喘患者血清NRP-1水平较高，提示其可作为基于年龄和吸烟状况预测早期气道重构的临床指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asia Pacific Allergy ALLERGY-

CiteScore

2.50

自引率

5.90%

发文量

期刊介绍： Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.