Sex differences in Acinetobacter baumannii infections: A comprehensive analysis of antibiotic resistance patterns in Hebei Province, China.

IF 2.4 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2025-07-25 DOI:10.1016/j.ajic.2025.07.011

Xiaoxuan Liu, Pu Qin, Hainan Wen, Weigang Wang, Qiuyue Huo, Qianqing Li, Jianhong Zhao

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引用次数: 0

Abstract

Background: To investigate the clinical distribution and antimicrobial resistance patterns of Acinetobacter baumannii in Hebei Province, with a focus on sex-based differences.

Methods: Surveillance data from 45 hospitals across Hebei Province were retrospectively analyzed from January 2020 to December 2022. Isolates were stratified by patient sex, age group, and specimen type. Data were processed using WHONET 5.6 and GraphPad Prism 8.4.0.

Results: A total of 27,754 A baumannii strains were collected, with 84.0% isolated from respiratory specimens. Male patients accounted for 65.9% of cases, nearly double that of females. Isolates from males showed higher resistance rates to β-lactamase inhibitor combinations, fluoroquinolones, cephalosporins, aminoglycosides, and carbapenems, particularly in the 15 to 50-year age group. Sex-related differences in resistance were also influenced by infection site.

Conclusions: Marked sex differences exist in A baumannii infection and antibiotic resistance patterns in Hebei Province, especially among males of reproductive age. These findings highlight the potential role of sex-specific factors in antimicrobial resistance and may inform targeted prevention and treatment strategies.

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鲍曼不动杆菌感染的性别差异：河北省抗生素耐药模式的综合分析。

目的：了解河北省鲍曼不动杆菌的临床分布及耐药模式，并探讨其性别差异。方法：回顾性分析河北省45家医院2020年1月至2022年12月的监测数据。分离株按患者性别、年龄组和标本类型分层。使用WHONET 5.6和GraphPad Prism 8.4.0对数据进行处理。结果：共检获鲍曼不动杆菌27754株，其中84.0%来自呼吸道标本。男性占65.9%，几乎是女性的两倍。男性分离株对β-内酰胺酶抑制剂、氟喹诺酮类药物、头孢菌素、氨基糖苷类药物和碳青霉烯类药物的耐药率较高，特别是在15-50岁年龄组。耐药的性别差异也受感染部位的影响。结论：河北省鲍曼不动杆菌感染及耐药模式存在明显的性别差异，育龄男性感染差异更明显。这些发现突出了性别特异性因素在抗菌素耐药性中的潜在作用，并可能为有针对性的预防和治疗策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)