Caterina Dalmaso, Pablo Javier Blanco, Lucas Omar Müller
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引用次数: 0
Abstract
We present a 1D-0D model that couples a 0D description of lung mechanics to the closed-loop Anatomically-Detailed Arterial-Venous Network (ADAVN) model. We show that our model can satisfactorily reproduce a set of cardiovascular indices of interest observed in healthy young males at rest. Next, we assess the impact of respiration on cardiac performance and on the periodicity and average values of pressure and flow waveforms in different vascular districts. In particular, our results confirm that respiration has a fundamental pumping function, which aids venous return, and that its action affects mainly the average of haemodynamic variables on the arterial side, while on the venous side it has a significant effect on wave periodicity and triggers a complex interplay in terms of waveform conformation. Additionally, we assess the sensitivity of model predictions to variations in model parameters through a local sensitivity analysis, both in the presence and absence of respiration, highlighting a strong relationship between the arterial and venous side of the model.
期刊介绍:
Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that
(1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury,
(2) identify and quantify mechanosensitive responses and their mechanisms,
(3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and
(4) report discoveries that advance therapeutic and diagnostic procedures.
Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.