Volumetric MRI Comparing Longitudinal Change in MOGAD to NMOSD, MS and Healthy Controls, and Disability Associations.

IF 7.7 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2025-07-29 DOI:10.1002/ana.27309

Amy Kunchok, Moein Amin, Tatchaporn Ongphichetmetha, Mengke Du, Robert Bermel, Tucker Harvey, Justin R Abbatemarco, Stephen E Jones, Jeffrey A Cohen, Daniel Ontaneda, Kunio Nakamura

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引用次数: 0

Abstract

Objectives: To examine volumetric magnetic resonance imaging (vMRI) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), compared to multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and healthy controls (HC).

Methods: Standardized vMRI in MOGAD were compared to age, sex, and disease duration matched MS (5:1), and non-matched NMOSD and HC, in mixed linear models with time and group interactions. Disability assessments included; patient determined disease steps (PDDS), manual dexterity (MDT), walking speed (WST), processing speed (PST), and contrast sensitivity tests (CST). Correlations between vMRI and disability in MOGAD were examined.

Results: A total of 293 patients were included; 32 MOGAD, 160 MS, 49 NMOSD, and 52 HC. MOGAD had a faster rate of volume loss in all brain regions compared to HC (p < 0.05). At baseline, MOGAD had preserved thalamic (0.000507, p = 0.005), caudate (0.000287, p = 0.004), and putamen (0.000341, p = 0.007) fractions than MS. Longitudinally, MOGAD had increased lateral ventricle fraction (LVF) (-0.000645, p = 0.032), but less hippocampal (0.000031, p = 0.044) and upper cervical cord area (UCCA) loss (1.482887, p = 0.005), compared to NMOSD. MOGAD had increased LVF (0.00529, p < 0.001), but less UCCA loss (0.538656, p = 0.042) longitudinally compared to MS. Among MOGAD, UCCA was associated with PDDS (-0.72, p = 0.004) and CST (0.60, p = 0.014). Whole brain fraction (WBF) was associated with PDDS (-0.66, p = 0.01) and PST (0.52, p = 0.019). LVF was associated with PDDS (0.78, p < 0.001).

Interpretation: MOGAD showed longitudinal brain volume loss compared to HC. Deep gray matter was relatively preserved compared to MS, while MS and NMOSD had greater UCCA loss, indicating regional differences in atrophy. Despite less overall atrophy, volume loss in MOGAD was associated with disability. ANN NEUROL 2025.

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体积MRI比较MOGAD与NMOSD、MS和健康对照的纵向变化以及残疾关联。

目的：将髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）的体积磁共振成像（vMRI）与多发性硬化症（MS）、视神经脊髓炎频谱障碍（NMOSD）和健康对照组（HC）进行比较。方法：将MOGAD患者的标准化vMRI与年龄、性别和病程匹配的MS（5:1）以及非匹配的NMOSD和HC进行比较，采用混合线性模型与时间和组间相互作用进行比较。包括残疾评估；患者确定疾病步数（PDDS）、手灵巧度（MDT）、步行速度（WST）、处理速度（PST）和对比敏感性试验（CST）。研究了vMRI与MOGAD致残的相关性。结果：共纳入293例患者；MOGAD 32例，MS 160例，NMOSD 49例，HC 52例。与HC相比，MOGAD在所有脑区域的体积损失速度更快(p)解释：MOGAD与HC相比显示纵向脑体积损失。与MS相比，深灰质相对保存，而MS和NMOSD的UCCA损失更大，表明萎缩的区域差异。尽管总体萎缩较少，但MOGAD的体积损失与残疾有关。Ann neurol 2025。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.