Carissa W. Tomas, Jacklynn M. Fitzgerald, C. Lexi Baird, Courtney C. Haswell, Chadi G. Abdallah, Michael Angstadt, Justin T. Baker, Hannah Berg, Jennifer U. Blackford, Josh Cisler, Andrew S. Cotton, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Terri A. deRoon-Cassini, Seth G. Disner, Wissam El Hage, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Xiaofu He, Ryan Herringa, David Hofmann, Ashley A. Huggins, Ahmed Hussain, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa L. Kaufman, Yoojean Kim, Anthony King, Saskia B. J. Koch, Sheri Koopowitz, Amit Lazarov, Lauren A. M. Lebois, Isreal Liberzon, Shmuel Lissek, Antje Manthey, Geoffrey May, Katie A. McLaughlin, Laura Nawijn, Steven M. Nelson, Yuval Neria, Jack B. Nitschke, Bunmi O. Olatunji, Miranda Olff, Matthew Peverill, Yann Quidé, Orren Ravid, Kerry Ressler, Marisa Ross, Lauren E. Salminen, Kelly Sambrook, Chiahao Shih, Anika Sierk, Scott R. Sponheim, Dan J. Stein, Jennifer Stevens, Thomas Straube, Benjamin Suarez-Jimenez, Paul M. Thompson, Nic J. A. van der Wee, Steven J. A. van der Werff, Sanne J. H. van Rooij, Mirjam van Zuiden, Dick J. Veltman, Robert R. J. M. Vermeiren, Henrik Walter, Xin Wang, Hong Xie, Xi Zhu, Sigal Zilcha-Mano, Christine L. Larson, Rajendra Morey
{"title":"Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study","authors":"Carissa W. Tomas, Jacklynn M. Fitzgerald, C. Lexi Baird, Courtney C. Haswell, Chadi G. Abdallah, Michael Angstadt, Justin T. Baker, Hannah Berg, Jennifer U. Blackford, Josh Cisler, Andrew S. Cotton, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Terri A. deRoon-Cassini, Seth G. Disner, Wissam El Hage, Negar Fani, Jessie L. Frijling, Evan M. Gordon, Daniel W. Grupe, Xiaofu He, Ryan Herringa, David Hofmann, Ashley A. Huggins, Ahmed Hussain, Jonathan Ipser, Neda Jahanshad, Tanja Jovanovic, Milissa L. Kaufman, Yoojean Kim, Anthony King, Saskia B. J. Koch, Sheri Koopowitz, Amit Lazarov, Lauren A. M. Lebois, Isreal Liberzon, Shmuel Lissek, Antje Manthey, Geoffrey May, Katie A. McLaughlin, Laura Nawijn, Steven M. Nelson, Yuval Neria, Jack B. Nitschke, Bunmi O. Olatunji, Miranda Olff, Matthew Peverill, Yann Quidé, Orren Ravid, Kerry Ressler, Marisa Ross, Lauren E. Salminen, Kelly Sambrook, Chiahao Shih, Anika Sierk, Scott R. Sponheim, Dan J. Stein, Jennifer Stevens, Thomas Straube, Benjamin Suarez-Jimenez, Paul M. Thompson, Nic J. A. van der Wee, Steven J. A. van der Werff, Sanne J. H. van Rooij, Mirjam van Zuiden, Dick J. Veltman, Robert R. J. M. Vermeiren, Henrik Walter, Xin Wang, Hong Xie, Xi Zhu, Sigal Zilcha-Mano, Christine L. Larson, Rajendra Morey","doi":"10.1002/hbm.70116","DOIUrl":null,"url":null,"abstract":"<p>Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven examinations of ROIs or canonical networks. Therefore, the current study used group independent components analysis (ICA) and graph theory principles to identify, characterize, and subsequently compare brain network dynamics and recurrent connectivity states in a large sample of trauma exposed individuals (<i>N</i> = 1035) with and without PTSD from the ENIGMA-PGC PTSD workgroup. Neither static FC nor dynamic FC results showed robust differences between groups. There were also no group differences in dwell time or number of transitions of recurrent connectivity states. This multi-cohort sample with heterogenous trauma types and demographic features offers a significantly larger scale approach than prior literature with smaller homogenous trauma cohorts. Heterogeneity of PTSD, especially within diffuse brain networks, may not be captured by evaluating only diagnostic groups, further work should be done to evaluate brain network dynamics with respect to specific symptom profiles and trauma types.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 11","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70116","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Brain Mapping","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hbm.70116","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven examinations of ROIs or canonical networks. Therefore, the current study used group independent components analysis (ICA) and graph theory principles to identify, characterize, and subsequently compare brain network dynamics and recurrent connectivity states in a large sample of trauma exposed individuals (N = 1035) with and without PTSD from the ENIGMA-PGC PTSD workgroup. Neither static FC nor dynamic FC results showed robust differences between groups. There were also no group differences in dwell time or number of transitions of recurrent connectivity states. This multi-cohort sample with heterogenous trauma types and demographic features offers a significantly larger scale approach than prior literature with smaller homogenous trauma cohorts. Heterogeneity of PTSD, especially within diffuse brain networks, may not be captured by evaluating only diagnostic groups, further work should be done to evaluate brain network dynamics with respect to specific symptom profiles and trauma types.
期刊介绍:
Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged.
Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.