High sensitive optical-chemical sensors based on optical fibers in a reflection scheme combined with C-shaped waveguides of MIP-microbeads

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-07-28 DOI:10.1016/j.talanta.2025.128647

Rosalba Pitruzzella , Filipa Sequeira , Alessandra Cutaia , Chiara Marzano , Francesco Arcadio , Catarina Cardoso Novo , Ricardo Oliveira , Maria Pesavento , Luigi Zeni , Giancarla Alberti , Rogerio Nunes Nogueira , Nunzio Cennamo

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引用次数: 0

Abstract

In order to monitor analytes in liquid matrices, optical fiber probes in reflection mode can be exploited in several application fields. This work presents a novel sensing approach based on C-shaped waveguides obtained by filling PVC C-shaped channels with microbeads of molecularly imprinted polymers (MIP-microbeads). Specifically, for the first time, MIP microbeads are used as a sensitive core of optical waveguides with several advantages. The MIP microbeads C-shaped waveguide is in contact with a polished plastic optical fiber (POF) at one end to connect the sensitive region with the light source and the detector in a reflection-based scheme via a simple POF-based splitter. As a proof of concept, the MIP-microbeads were prepared using 2-furaldehyde (2-FAL) as the template to compare the results with other optical fiber sensors. Moreover, to highlight the performance improvement of the proposed sensing approach compared to MIP-based configurations, a sensor based on an MIP (MIP-mass sensor) instead of MIP-microbeads has been developed, tested, and compared with the MIP-microbeads sensor and the state-of-the-art.

The results obtained via the MIP-microbeads sensor demonstrated the best performance, with an ultra-low detection limit at a pico-nano molar level and an ultra-wide detection concentration range of about four orders of magnitude. Moreover, the proposed optical-chemical sensor probe is small-size (at a micron scale), simple to realize, low-cost, mechanically robust, suitable for installation even in extreme conditions, and can be used in a real scenario where a reflection scheme sensor is required. An experimental test in the food application field is reported.

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基于反射方案的光纤与mip微珠c形波导结合的高灵敏度光化学传感器

为了监测液体基质中的分析物，反射模式的光纤探针可以在许多应用领域得到开发。这项工作提出了一种新的基于c形波导的传感方法，该方法通过用分子印迹聚合物微珠（mip微珠）填充PVC c形通道获得。具体来说，MIP微珠首次被用作光波导的敏感核心，具有几个优点。MIP微珠c形波导的一端与抛光塑料光纤（POF）接触，通过一个简单的基于POF的分配器以基于反射的方案将敏感区域与光源和检测器连接起来。作为概念验证，以2-呋喃醛（2-FAL）为模板制备了mip微珠，并将结果与其他光纤传感器进行了比较。此外，与基于MIP的配置相比，为了突出所提出的传感方法的性能改进，开发了一种基于MIP （MIP质量传感器）而不是MIP微珠的传感器，对其进行了测试，并与MIP微珠传感器和最新技术进行了比较。通过mip微珠传感器获得的结果显示了最佳性能，具有在皮纳米摩尔水平上的超低检测限和约4个数量级的超宽检测浓度范围。此外，所提出的光化学传感器探头尺寸小（微米级），易于实现，成本低，机械坚固，即使在极端条件下也适合安装，并且可以在需要反射方案传感器的实际场景中使用。报道了一项食品应用领域的试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.