Transition-metal-free decarboxylative acylation of sulfoximines: An efficient route to N-(ortho-aminobenzoyl)sulfoximines

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-28 DOI:10.1016/j.tet.2025.134867

Meng Ding, Qingle Zeng

引用次数: 0

Abstract

A transition-metal-free decarboxylative acylation strategy for constructing C–N bonds in sulfoximines and isatoic anhydrides is reported. This method enables the synthesis of 26 N-(ortho-aminobenzoyl)sulfoximines in 52 %–82 % yields, featuring gram-scale feasibility and versatile post-modifications for potential bioactive derivatives.

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亚砜亚胺的无过渡金属脱羧酰化：N-（邻氨基苯甲酰）亚砜亚胺的有效途径

报道了一种不含过渡金属的脱羧酰化策略，用于在亚砜亚胺和异核酸酐中构建C-N键。该方法能够以52% - 82%的收率合成26个N-（邻氨基苯甲酰）亚砜亚胺，具有克级可行性和多种潜在生物活性衍生物的后修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.