Clinical characteristics and surgical outcomes of gross total resection in pediatric low-grade epilepsy-associated brain tumors: A retrospective study

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-07-30 DOI:10.1016/j.yebeh.2025.110639

Xinyu Dong, Yuxin Wu, Difei Wang, Han Xiao, Bin Zou, Yudong Zhou, Xuan Zhai

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Abstract

Purpose

This study aimed to investigate the clinical characteristics and identify risk factors associated with postoperative seizure outcomes in pediatric patients with low-grade epilepsy-associated brain tumors (LEATs) who underwent gross total resection (GTR).

Methods

We retrospectively analyzed the clinical data of pediatric patients who underwent GTR of LEATs. Descriptive statistics were used to summarize the clinical features, and patients were categorized into two groups based on postoperative seizure outcomes: seizure-free and non-seizure-free. Binary logistic regression analysis was performed to identify independent risk factors for failure to achieve seizure freedom.

Results

A total of 75 pediatric patients with LEATs who underwent GTR were included in the study. Among them, 58 (77.3 %) achieved seizure freedom, while 17 (22.7 %) remained non-seizure-free postoperatively. Binary logistic regression analysis identified longer epilepsy duration (OR = 1.03, p = 0.034), the number of antiepileptic drugs (AEDs) (OR = 10.90, p = 0.005), and non-temporal lobe tumor location (OR = 6.02, p = 0.028) as significant independent risk factors for persistent postoperative seizures.

Conclusions

Our findings suggest that even after gross total resection, a prolonged history of epilepsy, extratemporal tumor location, and polytherapy with AEDs are associated with a lower likelihood of achieving seizure freedom. Early surgical intervention and comprehensive preoperative assessment may help optimize postoperative seizure outcomes in pediatric patients with LEATs.

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儿童低级别癫痫相关脑肿瘤全切除术的临床特点和手术结果：一项回顾性研究

目的：本研究旨在探讨小儿低级别癫痫相关脑肿瘤（LEATs）行全切除（GTR）的临床特点，并确定与术后癫痫发作结局相关的危险因素。方法回顾性分析小儿LEATs行GTR的临床资料。采用描述性统计方法总结临床特征，并根据患者术后发作结局将患者分为无发作组和非无发作组。进行二元logistic回归分析，以确定未能实现癫痫发作自由的独立危险因素。结果本研究共纳入75例leat患儿行GTR。其中58例（77.3%）术后癫痫发作解除，17例（22.7%）术后癫痫未发作。二元logistic回归分析发现，较长的癫痫持续时间（OR = 1.03, p = 0.034）、抗癫痫药物（aed）数量（OR = 10.90, p = 0.005）和非颞叶肿瘤位置（OR = 6.02, p = 0.028）是术后持续癫痫发作的重要独立危险因素。结论我们的研究结果表明，即使在全切除后，长期的癫痫病史、颞外肿瘤位置和使用aed的多重治疗与癫痫发作自由的可能性较低有关。早期手术干预和全面的术前评估可能有助于优化leat患儿术后癫痫发作结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.